Characterization of human breast cancer by scanning acoustic microscopy

Di Chen, Eugene Malyarenko, Fedar Seviaryn, Ye Yuan, Mark E. Sherman, Sudeshna Bandyopadhyay, Gretchen Gierach, Christopher W. Greenway, Elena Maeva, Emil Strumban, Neb Duric, Roman Maev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Objectives: The purpose of this study was to characterize human breast cancer tissues by the measurement of microacoustic properties. Methods: We investigated eight breast cancer patients using acoustic microscopy. For each patient, seven blocks of tumor tissue were collected from seven different positions around a tumor mass. Frozen sections (10 micrometer, μm) of human breast cancer tissues without staining and fixation were examined in a scanning acoustic microscope with focused transducers at 80 and 200 MHz. Hematoxylin and Eosin (H&E) stained sections from the same frozen breast cancer tissues were imaged by optical microscopy for comparison. Results: The results of acoustic imaging showed that acoustic attenuation and sound speed in cancer cell-rich tissue regions were significantly decreased compared with the surrounding tissue regions, where most components are normal cells/tissues, such as fibroblasts, connective tissue and lymphocytes. Our observation also showed that the ultrasonic properties were influenced by arrangements of cells and tissue patterns. Conclusions: Our data demonstrate that attenuation and sound speed imaging can provide biomechanical information of the tumor and normal tissues. The results also demonstrate the potential of acoustic microscopy as an auxiliary method for operative detection and localization of cancer affected regions.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2013
Subtitle of host publicationUltrasonic Imaging, Tomography, and Therapy
Volume8675
DOIs
StatePublished - 2013
EventMedical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy - Lake Buena Vista, FL, United States
Duration: Feb 12 2013Feb 14 2013

Other

OtherMedical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy
CountryUnited States
CityLake Buena Vista, FL
Period2/12/132/14/13

Fingerprint

Acoustic Microscopy
breast
cancer
Tissue
Breast Neoplasms
microscopy
scanning
acoustics
Acoustics
tumors
Tumors
Frozen Sections
Neoplasms
acoustic microscopes
acoustic imaging
connective tissue
Acoustic waves
acoustic attenuation
Acoustic microscopes
Acoustic imaging

Keywords

  • Acoustic attenuation
  • Acoustic microscopy
  • Histology
  • Human breast cancer
  • Pathology
  • Sound speed

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Chen, D., Malyarenko, E., Seviaryn, F., Yuan, Y., Sherman, M. E., Bandyopadhyay, S., ... Maev, R. (2013). Characterization of human breast cancer by scanning acoustic microscopy. In Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy (Vol. 8675). [86750M] https://doi.org/10.1117/12.2008660

Characterization of human breast cancer by scanning acoustic microscopy. / Chen, Di; Malyarenko, Eugene; Seviaryn, Fedar; Yuan, Ye; Sherman, Mark E.; Bandyopadhyay, Sudeshna; Gierach, Gretchen; Greenway, Christopher W.; Maeva, Elena; Strumban, Emil; Duric, Neb; Maev, Roman.

Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy. Vol. 8675 2013. 86750M.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, D, Malyarenko, E, Seviaryn, F, Yuan, Y, Sherman, ME, Bandyopadhyay, S, Gierach, G, Greenway, CW, Maeva, E, Strumban, E, Duric, N & Maev, R 2013, Characterization of human breast cancer by scanning acoustic microscopy. in Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy. vol. 8675, 86750M, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, Lake Buena Vista, FL, United States, 2/12/13. https://doi.org/10.1117/12.2008660
Chen D, Malyarenko E, Seviaryn F, Yuan Y, Sherman ME, Bandyopadhyay S et al. Characterization of human breast cancer by scanning acoustic microscopy. In Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy. Vol. 8675. 2013. 86750M https://doi.org/10.1117/12.2008660
Chen, Di ; Malyarenko, Eugene ; Seviaryn, Fedar ; Yuan, Ye ; Sherman, Mark E. ; Bandyopadhyay, Sudeshna ; Gierach, Gretchen ; Greenway, Christopher W. ; Maeva, Elena ; Strumban, Emil ; Duric, Neb ; Maev, Roman. / Characterization of human breast cancer by scanning acoustic microscopy. Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy. Vol. 8675 2013.
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