Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

Şükrü Tüzmen; Galen Hostetter; Aprill Watanabe; Cumhur Ekmekçi; Patricia E. Carrigan; Ishaiahu Shechter; Olli Kallioniemi; Laurence J. Miller; Spyro Mousses

doi:10.2217/pme-2016-0058

Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

Şükrü Tüzmen, Galen Hostetter, Aprill Watanabe, Cumhur Ekmekçi, Patricia E. Carrigan, Ishaiahu Shechter, Olli Kallioniemi, Laurence J. Miller, Spyro Mousses

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.

Original language	English (US)
Pages (from-to)	51-65
Number of pages	15
Journal	Personalized Medicine
Volume	16
Issue number	1
DOIs	https://doi.org/10.2217/pme-2016-0058
State	Published - Jan 1 2019

Keywords

FDFT1
TMA
cancer
cholesterol
gene expression
immunohistochemistry
lipidrafts
microdomains
plasma membrane
qPCR

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.2217/pme-2016-0058

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title = "Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer",

abstract = "Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.",

keywords = "FDFT1, TMA, cancer, cholesterol, gene expression, immunohistochemistry, lipidrafts, microdomains, plasma membrane, qPCR",

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year = "2019",

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doi = "10.2217/pme-2016-0058",

language = "English (US)",

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T1 - Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

AU - Tüzmen, Şükrü

AU - Hostetter, Galen

AU - Watanabe, Aprill

AU - Ekmekçi, Cumhur

AU - Carrigan, Patricia E.

AU - Shechter, Ishaiahu

AU - Kallioniemi, Olli

AU - Miller, Laurence J.

AU - Mousses, Spyro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.

AB - Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.

KW - FDFT1

KW - TMA

KW - cancer

KW - cholesterol

KW - gene expression

KW - immunohistochemistry

KW - lipidrafts

KW - microdomains

KW - plasma membrane

KW - qPCR

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SN - 1741-0541

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JO - Personalized Medicine

JF - Personalized Medicine

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ER -

Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

Abstract

Keywords

ASJC Scopus subject areas

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