Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma

Bing Luo; Mengyang Liu; Yan Chao; Yun Wang; Yongzheng Jing; Zhifu Sun

doi:10.1007/s00705-011-1148-z

Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma

Bing Luo, Mengyang Liu, Yan Chao, Yun Wang, Yongzheng Jing, Zhifu Sun

Health Sciences Research

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.

Original language	English (US)
Pages (from-to)	207-216
Number of pages	10
Journal	Archives of Virology
Volume	157
Issue number	2
DOIs	https://doi.org/10.1007/s00705-011-1148-z
State	Published - Feb 1 2012

Fingerprint

ASJC Scopus subject areas

Virology

Cite this

Luo, B., Liu, M., Chao, Y., Wang, Y., Jing, Y., & Sun, Z. (2012). Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma. Archives of Virology, 157(2), 207-216. https://doi.org/10.1007/s00705-011-1148-z

@article{dc366d723e434183a76f70a71cd3e9b2,

title = "Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma",

abstract = "To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.",

author = "Bing Luo and Mengyang Liu and Yan Chao and Yun Wang and Yongzheng Jing and Zhifu Sun",

year = "2012",

month = feb

day = "1",

doi = "10.1007/s00705-011-1148-z",

language = "English (US)",

volume = "157",

pages = "207--216",

journal = "Archives of Virology",

issn = "0304-8608",

publisher = "Springer Wien",

number = "2",

}

TY - JOUR

T1 - Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma

AU - Luo, Bing

AU - Liu, Mengyang

AU - Chao, Yan

AU - Wang, Yun

AU - Jing, Yongzheng

AU - Sun, Zhifu

PY - 2012/2/1

Y1 - 2012/2/1

N2 - To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.

AB - To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.

UR - http://www.scopus.com/inward/record.url?scp=84856367258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856367258&partnerID=8YFLogxK

U2 - 10.1007/s00705-011-1148-z

DO - 10.1007/s00705-011-1148-z

M3 - Article

C2 - 22038027

AN - SCOPUS:84856367258

VL - 157

SP - 207

EP - 216

JO - Archives of Virology

JF - Archives of Virology

SN - 0304-8608

IS - 2

ER -

Access to Document

10.1007/s00705-011-1148-z