Abstract
To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 207-216 |
| Number of pages | 10 |
| Journal | Archives of Virology |
| Volume | 157 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2012 |
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ASJC Scopus subject areas
- Virology
Cite this
Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma. / Luo, Bing; Liu, Mengyang; Chao, Yan; Wang, Yun; Jing, Yongzheng; Sun, Zhifu D.
In: Archives of Virology, Vol. 157, No. 2, 02.2012, p. 207-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma
AU - Luo, Bing
AU - Liu, Mengyang
AU - Chao, Yan
AU - Wang, Yun
AU - Jing, Yongzheng
AU - Sun, Zhifu D
PY - 2012/2
Y1 - 2012/2
N2 - To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.
AB - To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.
UR - http://www.scopus.com/inward/record.url?scp=84856367258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856367258&partnerID=8YFLogxK
U2 - 10.1007/s00705-011-1148-z
DO - 10.1007/s00705-011-1148-z
M3 - Article
C2 - 22038027
AN - SCOPUS:84856367258
VL - 157
SP - 207
EP - 216
JO - Archives of Virology
JF - Archives of Virology
SN - 0304-8608
IS - 2
ER -