Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma

Bing Luo, Mengyang Liu, Yan Chao, Yun Wang, Yongzheng Jing, Zhifu Sun

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Abstract

To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.

Original languageEnglish (US)
Pages (from-to)207-216
Number of pages10
JournalArchives of Virology
Volume157
Issue number2
DOIs
StatePublished - Feb 1 2012

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ASJC Scopus subject areas

  • Virology

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