Characterization of endoscopic ultrasound fine-needle aspiration cytology by targeted next-generation sequencing and theranostic potential

Ferga C. Gleeson, Benjamin R. Kipp, Sarah E. Kerr, Jesse S. Voss, Konstantinos N. Lazaridis, David A. Katzka, Michael J. Levy

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Determination of tumor genetic architecture based on tissue analysis yields important information on signaling pathways involved in cancer pathogenesis and plays a growing role in choosing the optimal medical management of malignancies. Specifically, the advent of next-generation sequencing has led to a rapidly evolving era of relatively inexpensive, high-throughput DNA sequencing of tumors. One such example is multiplexed tumor genotyping (ie, panel testing) of more than 2800 mutations across 50 commonly mutated cancer-associated genes. This resulting mutational landscape shows medically actionable pathogenic alterations to optimize antitumor therapy. We recently assessed the performance and outcome of targeted next-generation sequencing with archived endoscopic ultrasound fine-needle aspirates across a broad range of primary and metastatic sites with encouraging accuracy. As a result, endoscopic ultrasound has the potential to move from a test for diagnosis or confirmation of malignancy, to one in which it could facilitate the personalization of cancer-directed therapy.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalClinical Gastroenterology and Hepatology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Endoscopic ultrasound fine-needle aspiration
  • Individualized medicine
  • Malignant cytology
  • Targeted next-generation sequencing
  • Theranostics

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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