Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma

Eric C. Weinman, Patrick C. Roche, Jan Kasperbauer, Steve S. Cha, Dan J. Sargent, John Cheville, Linda M. Murphy, Lieping Chen, Peter J. Wettstein, Bobbie Gostout, Soldano Ferrone, Scott E. Strome

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31 Citations (Scopus)

Abstract

BACKGROUND. There is a statistically significant association between human leukocyte antigen (HLA) Class I antigen expression and improved prognosis for some patients. This association reflects the control of tumor growth by HLA Class I antigen-restricted, tumor-associated antigen-specific cytolytic T cells. However, progression of other malignant diseases is not associated with the loss of HLA expression. These observations show that the poor prognosis of a subset of tumors, despite high HLA Class I antigen expression, may reflect the development of alternative mechanisms utilized by tumor cells to escape from immune recognition and destruction. METHODS. The authors evaluated the possible correlation between the expression of the antiapoptosis gene, Survivin, HLA Class I, and progression of tonsillar squamous cell carcinomas (TSCC) lesions. Tissue microarrays were constructed from primary TSCC, metastatically involved lymph nodes, adjacent normal mucosa, and tonsillar parenchyma excised for nonmalignant conditions. RESULTS. Immunoperoxidase staining of tissue sections demonstrated that Survivin expression is significantly higher (P < 0.001) in malignant tumors than in normal tissue samples. In addition, Survivin expression is significantly higher (P = 0.05) in metastatic than in primary lesions. Survivin expression in primary lesions correlated positively with delta (P = 0.025), tapasin (P = 0.028), and HLA Class I antigen (P = 0.006) expression. The expression patterns of delta, tapasin, HLA Class I antigen, β-2-microglobulin, and Survivin did not demonstrate any significant association with the clinical course of disease. CONCLUSIONS. For TSCC that maintain the expression of HLA Class I antigen, overexpression of Survivin may provide an alternative explanation for tumor progression.

Original languageEnglish (US)
Pages (from-to)2203-2211
Number of pages9
JournalCancer
Volume97
Issue number9
DOIs
StatePublished - May 1 2003

Fingerprint

Antigen Presentation
HLA Antigens
Histocompatibility Antigens Class I
Squamous Cell Carcinoma
Neoplasms
Neoplasm Antigens
Mucous Membrane
Lymph Nodes
Staining and Labeling
T-Lymphocytes
Gene Expression
Growth

Keywords

  • Head and neck carcinoma
  • Human leukocyte antigen (HLA) Class I antigen processing
  • Squamous cell neoplasms
  • Survivin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Weinman, E. C., Roche, P. C., Kasperbauer, J., Cha, S. S., Sargent, D. J., Cheville, J., ... Strome, S. E. (2003). Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma. Cancer, 97(9), 2203-2211. https://doi.org/10.1002/cncr.11311

Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma. / Weinman, Eric C.; Roche, Patrick C.; Kasperbauer, Jan; Cha, Steve S.; Sargent, Dan J.; Cheville, John; Murphy, Linda M.; Chen, Lieping; Wettstein, Peter J.; Gostout, Bobbie; Ferrone, Soldano; Strome, Scott E.

In: Cancer, Vol. 97, No. 9, 01.05.2003, p. 2203-2211.

Research output: Contribution to journalArticle

Weinman, EC, Roche, PC, Kasperbauer, J, Cha, SS, Sargent, DJ, Cheville, J, Murphy, LM, Chen, L, Wettstein, PJ, Gostout, B, Ferrone, S & Strome, SE 2003, 'Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma', Cancer, vol. 97, no. 9, pp. 2203-2211. https://doi.org/10.1002/cncr.11311
Weinman, Eric C. ; Roche, Patrick C. ; Kasperbauer, Jan ; Cha, Steve S. ; Sargent, Dan J. ; Cheville, John ; Murphy, Linda M. ; Chen, Lieping ; Wettstein, Peter J. ; Gostout, Bobbie ; Ferrone, Soldano ; Strome, Scott E. / Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma. In: Cancer. 2003 ; Vol. 97, No. 9. pp. 2203-2211.
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abstract = "BACKGROUND. There is a statistically significant association between human leukocyte antigen (HLA) Class I antigen expression and improved prognosis for some patients. This association reflects the control of tumor growth by HLA Class I antigen-restricted, tumor-associated antigen-specific cytolytic T cells. However, progression of other malignant diseases is not associated with the loss of HLA expression. These observations show that the poor prognosis of a subset of tumors, despite high HLA Class I antigen expression, may reflect the development of alternative mechanisms utilized by tumor cells to escape from immune recognition and destruction. METHODS. The authors evaluated the possible correlation between the expression of the antiapoptosis gene, Survivin, HLA Class I, and progression of tonsillar squamous cell carcinomas (TSCC) lesions. Tissue microarrays were constructed from primary TSCC, metastatically involved lymph nodes, adjacent normal mucosa, and tonsillar parenchyma excised for nonmalignant conditions. RESULTS. Immunoperoxidase staining of tissue sections demonstrated that Survivin expression is significantly higher (P < 0.001) in malignant tumors than in normal tissue samples. In addition, Survivin expression is significantly higher (P = 0.05) in metastatic than in primary lesions. Survivin expression in primary lesions correlated positively with delta (P = 0.025), tapasin (P = 0.028), and HLA Class I antigen (P = 0.006) expression. The expression patterns of delta, tapasin, HLA Class I antigen, β-2-microglobulin, and Survivin did not demonstrate any significant association with the clinical course of disease. CONCLUSIONS. For TSCC that maintain the expression of HLA Class I antigen, overexpression of Survivin may provide an alternative explanation for tumor progression.",
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AU - Weinman, Eric C.

AU - Roche, Patrick C.

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AU - Cha, Steve S.

AU - Sargent, Dan J.

AU - Cheville, John

AU - Murphy, Linda M.

AU - Chen, Lieping

AU - Wettstein, Peter J.

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AU - Strome, Scott E.

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N2 - BACKGROUND. There is a statistically significant association between human leukocyte antigen (HLA) Class I antigen expression and improved prognosis for some patients. This association reflects the control of tumor growth by HLA Class I antigen-restricted, tumor-associated antigen-specific cytolytic T cells. However, progression of other malignant diseases is not associated with the loss of HLA expression. These observations show that the poor prognosis of a subset of tumors, despite high HLA Class I antigen expression, may reflect the development of alternative mechanisms utilized by tumor cells to escape from immune recognition and destruction. METHODS. The authors evaluated the possible correlation between the expression of the antiapoptosis gene, Survivin, HLA Class I, and progression of tonsillar squamous cell carcinomas (TSCC) lesions. Tissue microarrays were constructed from primary TSCC, metastatically involved lymph nodes, adjacent normal mucosa, and tonsillar parenchyma excised for nonmalignant conditions. RESULTS. Immunoperoxidase staining of tissue sections demonstrated that Survivin expression is significantly higher (P < 0.001) in malignant tumors than in normal tissue samples. In addition, Survivin expression is significantly higher (P = 0.05) in metastatic than in primary lesions. Survivin expression in primary lesions correlated positively with delta (P = 0.025), tapasin (P = 0.028), and HLA Class I antigen (P = 0.006) expression. The expression patterns of delta, tapasin, HLA Class I antigen, β-2-microglobulin, and Survivin did not demonstrate any significant association with the clinical course of disease. CONCLUSIONS. For TSCC that maintain the expression of HLA Class I antigen, overexpression of Survivin may provide an alternative explanation for tumor progression.

AB - BACKGROUND. There is a statistically significant association between human leukocyte antigen (HLA) Class I antigen expression and improved prognosis for some patients. This association reflects the control of tumor growth by HLA Class I antigen-restricted, tumor-associated antigen-specific cytolytic T cells. However, progression of other malignant diseases is not associated with the loss of HLA expression. These observations show that the poor prognosis of a subset of tumors, despite high HLA Class I antigen expression, may reflect the development of alternative mechanisms utilized by tumor cells to escape from immune recognition and destruction. METHODS. The authors evaluated the possible correlation between the expression of the antiapoptosis gene, Survivin, HLA Class I, and progression of tonsillar squamous cell carcinomas (TSCC) lesions. Tissue microarrays were constructed from primary TSCC, metastatically involved lymph nodes, adjacent normal mucosa, and tonsillar parenchyma excised for nonmalignant conditions. RESULTS. Immunoperoxidase staining of tissue sections demonstrated that Survivin expression is significantly higher (P < 0.001) in malignant tumors than in normal tissue samples. In addition, Survivin expression is significantly higher (P = 0.05) in metastatic than in primary lesions. Survivin expression in primary lesions correlated positively with delta (P = 0.025), tapasin (P = 0.028), and HLA Class I antigen (P = 0.006) expression. The expression patterns of delta, tapasin, HLA Class I antigen, β-2-microglobulin, and Survivin did not demonstrate any significant association with the clinical course of disease. CONCLUSIONS. For TSCC that maintain the expression of HLA Class I antigen, overexpression of Survivin may provide an alternative explanation for tumor progression.

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KW - Squamous cell neoplasms

KW - Survivin

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