Characterization of an intronless human calmodulin-like pseudogene

Markus Koller, Emanuel E. Strehler

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We report the isolation and characterization of a human genomic clone encoding a calmodulin-like pseudogene. It contains an open reading frame of 444 nucleotides, not interrupted by introns. The nucleotide sequence of the open reading frame shows 80%, 71% and 69% identity to the previously reported human calmodulin cDNAs λht6 [17], hCWP [22], and λhCE1 [23], respectively. The derived amino acid sequence has only 85% identity to vertebrate calmodulin, but shows four potentially functional Ca2+-binding loops. In the human tissues tested, this pseudogene is not expressed, though gene structure including promoter elements and a putative polyadenylation site seems to be intact.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalFEBS Letters
Volume239
Issue number1
DOIs
StatePublished - Oct 24 1988

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Keywords

  • Calmodulin
  • Calmodulin-like pseudogene

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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