Characterization of 10 New Polymorphic Dinucleotide Repeats and Generation of a High-Density Microsatellite-Based Physical Map of the BRCA1 Region of Chromosome 17q21

Fergus J Couch, Sam Kiousis, Lucio H. Castilla, Junzhe Xu, Settara C. Chandrasekharappa, Jeffrey S. Chamberlain, Francis S. Collins, Barbara L. Weber

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Abstract

A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and characterized. These markers, along with previously published markers from the region, were localized on a physical map by STS content mapping of cosmids from the BRCA1 interval. This high-density STS map of the BRCA1 region will be useful for linkage studies of families with apparent inherited breast cancer and for loss of heterozygosity analysis of breast tumor DNAs.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalGenomics
Volume24
Issue number3
DOIs
StatePublished - Dec 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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