Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21

Fergus J. Couch; Sam Kiousis; Lucio H. Castilla; Junzhe Xu; Settara C. Chandrasekharappa; Jeffrey S. Chamberlain; Francis S. Collins; Barbara L. Weber

doi:10.1006/geno.1994.1647

Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21

Fergus J. Couch, Sam Kiousis, Lucio H. Castilla, Junzhe Xu, Settara C. Chandrasekharappa, Jeffrey S. Chamberlain, Francis S. Collins, Barbara L. Weber

Research output: Contribution to journal › Article › peer-review

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Abstract

A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and characterized. These markers, along with previously published markers from the region, were localized on a physical map by STS content mapping of cosmids from the BRCA1 interval. This high-density STS map of the BRCA1 region will be useful for linkage studies of families with apparent inherited breast cancer and for loss of heterozygosity analysis of breast tumor DNAs.

Original language	English (US)
Pages (from-to)	419-424
Number of pages	6
Journal	Genomics
Volume	24
Issue number	3
DOIs	https://doi.org/10.1006/geno.1994.1647
State	Published - Dec 1994

ASJC Scopus subject areas

Genetics

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title = "Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21",

abstract = "A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and characterized. These markers, along with previously published markers from the region, were localized on a physical map by STS content mapping of cosmids from the BRCA1 interval. This high-density STS map of the BRCA1 region will be useful for linkage studies of families with apparent inherited breast cancer and for loss of heterozygosity analysis of breast tumor DNAs.",

author = "Couch, {Fergus J.} and Sam Kiousis and Castilla, {Lucio H.} and Junzhe Xu and Chandrasekharappa, {Settara C.} and Chamberlain, {Jeffrey S.} and Collins, {Francis S.} and Weber, {Barbara L.}",

year = "1994",

month = dec,

doi = "10.1006/geno.1994.1647",

language = "English (US)",

volume = "24",

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T1 - Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21

AU - Couch, Fergus J.

AU - Kiousis, Sam

AU - Castilla, Lucio H.

AU - Xu, Junzhe

AU - Chandrasekharappa, Settara C.

AU - Chamberlain, Jeffrey S.

AU - Collins, Francis S.

AU - Weber, Barbara L.

PY - 1994/12

Y1 - 1994/12

N2 - A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and characterized. These markers, along with previously published markers from the region, were localized on a physical map by STS content mapping of cosmids from the BRCA1 interval. This high-density STS map of the BRCA1 region will be useful for linkage studies of families with apparent inherited breast cancer and for loss of heterozygosity analysis of breast tumor DNAs.

AB - A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and characterized. These markers, along with previously published markers from the region, were localized on a physical map by STS content mapping of cosmids from the BRCA1 interval. This high-density STS map of the BRCA1 region will be useful for linkage studies of families with apparent inherited breast cancer and for loss of heterozygosity analysis of breast tumor DNAs.

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Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21

Abstract

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