Characteristics of long-term survivors with multiple myeloma

A National Cancer Data Base analysis

Ronan W. Hsieh, Ronald S. Go, Jithma P. Abeykoon, Prashant Kapoor, Shaji K Kumar, Morie Gertz, Francis K. Buadi, Nelson Leung, Wilson Gonsalves, Taxiarchis Kourelis, Rahma M. Warsame, Angela Dispenzieri, Martha Lacy, Robert A. Kyle, S Vincent Rajkumar, Jonas Paludo

Research output: Contribution to journalArticle

Abstract

Background: There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods: The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of Diseases for Oncology (ICD-O) code 9732 from January 2004 to December 2006 and were divided into 4 groups based on overall survival (OS). Sociodemographic characteristics, treatment facility, and use of SCT were recorded. The univariate and multivariate analyses were performed using multiple logistic regression and Pearson chi-square tests. Results: A total of 26,986 patients with MM were identified. The median OS was 2.74 years. The majority of patients were male (54%), white (77%), insured (93%) and otherwise healthy (78%), lived in a metropolitan area (82%), were of high income (66%) and educational (58%) levels, and received treatment at nonacademic facilities (63%). Upfront SCT was used in 10% of patients. One in 6 patients (16%) were long-term survivors (group 4). When comparing group 4 (OS of ≥8.22 years) with the other groups (OS of <8.22 years), young age, female sex, high income and educational levels, residence in a rural area, insured status, no comorbidity, receipt of upfront SCT, and treatment at high-volume facilities were associated with long-term survival. Conclusions: Key differences in sociodemographic characteristics, patient volume at treatment facilities, and upfront SCT were associated with long-term survival. Improvements in health care access and health literacy, upfront SCT, and treatment at high-volume facilities might prolong patient survival.

Original languageEnglish (US)
JournalCancer
DOIs
StatePublished - Jan 1 2019

Fingerprint

Multiple Myeloma
Survivors
Stem Cell Transplantation
Databases
Survival
Neoplasms
Health Literacy
Therapeutics
International Classification of Diseases
Chi-Square Distribution
Comorbidity
Multivariate Analysis
Logistic Models
Delivery of Health Care
Population

Keywords

  • hematologic malignancy
  • multiple myeloma
  • National Cancer Data Base
  • plasma cell dyscrasia
  • stem cell transplantation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Characteristics of long-term survivors with multiple myeloma : A National Cancer Data Base analysis. / Hsieh, Ronan W.; Go, Ronald S.; Abeykoon, Jithma P.; Kapoor, Prashant; Kumar, Shaji K; Gertz, Morie; Buadi, Francis K.; Leung, Nelson; Gonsalves, Wilson; Kourelis, Taxiarchis; Warsame, Rahma M.; Dispenzieri, Angela; Lacy, Martha; Kyle, Robert A.; Rajkumar, S Vincent; Paludo, Jonas.

In: Cancer, 01.01.2019.

Research output: Contribution to journalArticle

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title = "Characteristics of long-term survivors with multiple myeloma: A National Cancer Data Base analysis",
abstract = "Background: There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods: The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of Diseases for Oncology (ICD-O) code 9732 from January 2004 to December 2006 and were divided into 4 groups based on overall survival (OS). Sociodemographic characteristics, treatment facility, and use of SCT were recorded. The univariate and multivariate analyses were performed using multiple logistic regression and Pearson chi-square tests. Results: A total of 26,986 patients with MM were identified. The median OS was 2.74 years. The majority of patients were male (54{\%}), white (77{\%}), insured (93{\%}) and otherwise healthy (78{\%}), lived in a metropolitan area (82{\%}), were of high income (66{\%}) and educational (58{\%}) levels, and received treatment at nonacademic facilities (63{\%}). Upfront SCT was used in 10{\%} of patients. One in 6 patients (16{\%}) were long-term survivors (group 4). When comparing group 4 (OS of ≥8.22 years) with the other groups (OS of <8.22 years), young age, female sex, high income and educational levels, residence in a rural area, insured status, no comorbidity, receipt of upfront SCT, and treatment at high-volume facilities were associated with long-term survival. Conclusions: Key differences in sociodemographic characteristics, patient volume at treatment facilities, and upfront SCT were associated with long-term survival. Improvements in health care access and health literacy, upfront SCT, and treatment at high-volume facilities might prolong patient survival.",
keywords = "hematologic malignancy, multiple myeloma, National Cancer Data Base, plasma cell dyscrasia, stem cell transplantation",
author = "Hsieh, {Ronan W.} and Go, {Ronald S.} and Abeykoon, {Jithma P.} and Prashant Kapoor and Kumar, {Shaji K} and Morie Gertz and Buadi, {Francis K.} and Nelson Leung and Wilson Gonsalves and Taxiarchis Kourelis and Warsame, {Rahma M.} and Angela Dispenzieri and Martha Lacy and Kyle, {Robert A.} and Rajkumar, {S Vincent} and Jonas Paludo",
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T1 - Characteristics of long-term survivors with multiple myeloma

T2 - A National Cancer Data Base analysis

AU - Hsieh, Ronan W.

AU - Go, Ronald S.

AU - Abeykoon, Jithma P.

AU - Kapoor, Prashant

AU - Kumar, Shaji K

AU - Gertz, Morie

AU - Buadi, Francis K.

AU - Leung, Nelson

AU - Gonsalves, Wilson

AU - Kourelis, Taxiarchis

AU - Warsame, Rahma M.

AU - Dispenzieri, Angela

AU - Lacy, Martha

AU - Kyle, Robert A.

AU - Rajkumar, S Vincent

AU - Paludo, Jonas

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods: The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of Diseases for Oncology (ICD-O) code 9732 from January 2004 to December 2006 and were divided into 4 groups based on overall survival (OS). Sociodemographic characteristics, treatment facility, and use of SCT were recorded. The univariate and multivariate analyses were performed using multiple logistic regression and Pearson chi-square tests. Results: A total of 26,986 patients with MM were identified. The median OS was 2.74 years. The majority of patients were male (54%), white (77%), insured (93%) and otherwise healthy (78%), lived in a metropolitan area (82%), were of high income (66%) and educational (58%) levels, and received treatment at nonacademic facilities (63%). Upfront SCT was used in 10% of patients. One in 6 patients (16%) were long-term survivors (group 4). When comparing group 4 (OS of ≥8.22 years) with the other groups (OS of <8.22 years), young age, female sex, high income and educational levels, residence in a rural area, insured status, no comorbidity, receipt of upfront SCT, and treatment at high-volume facilities were associated with long-term survival. Conclusions: Key differences in sociodemographic characteristics, patient volume at treatment facilities, and upfront SCT were associated with long-term survival. Improvements in health care access and health literacy, upfront SCT, and treatment at high-volume facilities might prolong patient survival.

AB - Background: There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods: The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of Diseases for Oncology (ICD-O) code 9732 from January 2004 to December 2006 and were divided into 4 groups based on overall survival (OS). Sociodemographic characteristics, treatment facility, and use of SCT were recorded. The univariate and multivariate analyses were performed using multiple logistic regression and Pearson chi-square tests. Results: A total of 26,986 patients with MM were identified. The median OS was 2.74 years. The majority of patients were male (54%), white (77%), insured (93%) and otherwise healthy (78%), lived in a metropolitan area (82%), were of high income (66%) and educational (58%) levels, and received treatment at nonacademic facilities (63%). Upfront SCT was used in 10% of patients. One in 6 patients (16%) were long-term survivors (group 4). When comparing group 4 (OS of ≥8.22 years) with the other groups (OS of <8.22 years), young age, female sex, high income and educational levels, residence in a rural area, insured status, no comorbidity, receipt of upfront SCT, and treatment at high-volume facilities were associated with long-term survival. Conclusions: Key differences in sociodemographic characteristics, patient volume at treatment facilities, and upfront SCT were associated with long-term survival. Improvements in health care access and health literacy, upfront SCT, and treatment at high-volume facilities might prolong patient survival.

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KW - National Cancer Data Base

KW - plasma cell dyscrasia

KW - stem cell transplantation

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