TY - JOUR
T1 - Characteristics of long-term survivors with multiple myeloma
T2 - A National Cancer Data Base analysis
AU - Hsieh, Ronan W.
AU - Go, Ronald S.
AU - Abeykoon, Jithma P.
AU - Kapoor, Prashant
AU - Kumar, Shaji K.
AU - Gertz, Morie A.
AU - Buadi, Francis K.
AU - Leung, Nelson
AU - Gonsalves, Wilson I.
AU - Kourelis, Taxiarchis V.
AU - Warsame, Rahma M.
AU - Dispenzieri, Angela
AU - Lacy, Martha Q.
AU - Kyle, Robert A.
AU - Rajkumar, S. Vincent
AU - Paludo, Jonas
N1 - Publisher Copyright:
© 2019 American Cancer Society
PY - 2019/10/15
Y1 - 2019/10/15
N2 - Background: There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods: The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of Diseases for Oncology (ICD-O) code 9732 from January 2004 to December 2006 and were divided into 4 groups based on overall survival (OS). Sociodemographic characteristics, treatment facility, and use of SCT were recorded. The univariate and multivariate analyses were performed using multiple logistic regression and Pearson chi-square tests. Results: A total of 26,986 patients with MM were identified. The median OS was 2.74 years. The majority of patients were male (54%), white (77%), insured (93%) and otherwise healthy (78%), lived in a metropolitan area (82%), were of high income (66%) and educational (58%) levels, and received treatment at nonacademic facilities (63%). Upfront SCT was used in 10% of patients. One in 6 patients (16%) were long-term survivors (group 4). When comparing group 4 (OS of ≥8.22 years) with the other groups (OS of <8.22 years), young age, female sex, high income and educational levels, residence in a rural area, insured status, no comorbidity, receipt of upfront SCT, and treatment at high-volume facilities were associated with long-term survival. Conclusions: Key differences in sociodemographic characteristics, patient volume at treatment facilities, and upfront SCT were associated with long-term survival. Improvements in health care access and health literacy, upfront SCT, and treatment at high-volume facilities might prolong patient survival.
AB - Background: There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods: The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of Diseases for Oncology (ICD-O) code 9732 from January 2004 to December 2006 and were divided into 4 groups based on overall survival (OS). Sociodemographic characteristics, treatment facility, and use of SCT were recorded. The univariate and multivariate analyses were performed using multiple logistic regression and Pearson chi-square tests. Results: A total of 26,986 patients with MM were identified. The median OS was 2.74 years. The majority of patients were male (54%), white (77%), insured (93%) and otherwise healthy (78%), lived in a metropolitan area (82%), were of high income (66%) and educational (58%) levels, and received treatment at nonacademic facilities (63%). Upfront SCT was used in 10% of patients. One in 6 patients (16%) were long-term survivors (group 4). When comparing group 4 (OS of ≥8.22 years) with the other groups (OS of <8.22 years), young age, female sex, high income and educational levels, residence in a rural area, insured status, no comorbidity, receipt of upfront SCT, and treatment at high-volume facilities were associated with long-term survival. Conclusions: Key differences in sociodemographic characteristics, patient volume at treatment facilities, and upfront SCT were associated with long-term survival. Improvements in health care access and health literacy, upfront SCT, and treatment at high-volume facilities might prolong patient survival.
KW - National Cancer Data Base
KW - hematologic malignancy
KW - multiple myeloma
KW - plasma cell dyscrasia
KW - stem cell transplantation
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U2 - 10.1002/cncr.32357
DO - 10.1002/cncr.32357
M3 - Article
C2 - 31251390
AN - SCOPUS:85068210100
SN - 0008-543X
VL - 125
SP - 3574
EP - 3581
JO - Cancer
JF - Cancer
IS - 20
ER -