Characteristics of long-term survivors with multiple myeloma: A National Cancer Data Base analysis

Ronan W. Hsieh, Ronald S. Go, Jithma P. Abeykoon, Prashant Kapoor, Shaji K. Kumar, Morie A. Gertz, Francis K. Buadi, Nelson Leung, Wilson I. Gonsalves, Taxiarchis V. Kourelis, Rahma M. Warsame, Angela Dispenzieri, Martha Q. Lacy, Robert A. Kyle, S. Vincent Rajkumar, Jonas Paludo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). Methods: The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500 cancer centers. Patients with MM were identified using the International Classification of Diseases for Oncology (ICD-O) code 9732 from January 2004 to December 2006 and were divided into 4 groups based on overall survival (OS). Sociodemographic characteristics, treatment facility, and use of SCT were recorded. The univariate and multivariate analyses were performed using multiple logistic regression and Pearson chi-square tests. Results: A total of 26,986 patients with MM were identified. The median OS was 2.74 years. The majority of patients were male (54%), white (77%), insured (93%) and otherwise healthy (78%), lived in a metropolitan area (82%), were of high income (66%) and educational (58%) levels, and received treatment at nonacademic facilities (63%). Upfront SCT was used in 10% of patients. One in 6 patients (16%) were long-term survivors (group 4). When comparing group 4 (OS of ≥8.22 years) with the other groups (OS of <8.22 years), young age, female sex, high income and educational levels, residence in a rural area, insured status, no comorbidity, receipt of upfront SCT, and treatment at high-volume facilities were associated with long-term survival. Conclusions: Key differences in sociodemographic characteristics, patient volume at treatment facilities, and upfront SCT were associated with long-term survival. Improvements in health care access and health literacy, upfront SCT, and treatment at high-volume facilities might prolong patient survival.

Original languageEnglish (US)
Pages (from-to)3574-3581
Number of pages8
JournalCancer
Volume125
Issue number20
DOIs
StatePublished - Oct 15 2019

Keywords

  • National Cancer Data Base
  • hematologic malignancy
  • multiple myeloma
  • plasma cell dyscrasia
  • stem cell transplantation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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