Characteristics of hepatitis C virus infection in HIV-infected people

C. L. Cooper, A. D. Badley, J. B. Angel

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Knowledge pertaining to hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infection is currently incomplete or conflicting. Several points are well studied, however. Plasma HCV RNA levels are higher in matched HIV-infected people than in HIV-seronegative control subjects and are inversely correlated with CD4+ T lymphocyte counts. HCV genotype does not appear to influence this value. Co-infected individuals develop histological and clinical features of HCV liver disease more rapidly than HIV-seronegative patients. Co-infected individuals appear to respond to interferon-alpha therapy equally as well as HIV-seronegative HCV-infected adults, but minimal information exists regarding the efficacy and toxicity of combination HCV therapy (interferon-alpha plus ribavirin) in this population. Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'. It is unclear whether long term, highly active antiretroviral therapy positively or negatively influences the natural history of HCV infection.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalCanadian Journal of Infectious Diseases
Volume12
Issue number3
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Antiretrovirals
  • HCV
  • HIV
  • Hepatitis
  • Hepatitis C virus
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Microbiology (medical)

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