Characteristics of hepatitis C virus infection in HIV-infected people

C. L. Cooper, Andrew David Badley, J. B. Angel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Knowledge pertaining to hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infection is currently incomplete or conflicting. Several points are well studied, however. Plasma HCV RNA levels are higher in matched HIV-infected people than in HIV-seronegative control subjects and are inversely correlated with CD4+ T lymphocyte counts. HCV genotype does not appear to influence this value. Co-infected individuals develop histological and clinical features of HCV liver disease more rapidly than HIV-seronegative patients. Co-infected individuals appear to respond to interferon-alpha therapy equally as well as HIV-seronegative HCV-infected adults, but minimal information exists regarding the efficacy and toxicity of combination HCV therapy (interferon-alpha plus ribavirin) in this population. Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'. It is unclear whether long term, highly active antiretroviral therapy positively or negatively influences the natural history of HCV infection.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalCanadian Journal of Infectious Diseases
Volume12
Issue number3
StatePublished - 2001
Externally publishedYes

Fingerprint

Virus Diseases
Hepacivirus
HIV
Highly Active Antiretroviral Therapy
Interferon-alpha
Immune Reconstitution Inflammatory Syndrome
Ribavirin
CD4 Lymphocyte Count
Natural History
Coinfection
Liver Diseases
Genotype
RNA
T-Lymphocytes
Liver
Therapeutics
Population

Keywords

  • Antiretrovirals
  • HCV
  • Hepatitis
  • Hepatitis C virus
  • HIV
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Characteristics of hepatitis C virus infection in HIV-infected people. / Cooper, C. L.; Badley, Andrew David; Angel, J. B.

In: Canadian Journal of Infectious Diseases, Vol. 12, No. 3, 2001, p. 157-163.

Research output: Contribution to journalArticle

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