Characteristics of acute pain attacks in patients with irritable bowel syndrome meeting Rome III criteria

Per M. Hellström, Yuri Ann Saito Loftus, Peter Bytzer, Jan Tack, Stefan Mueller-Lissner, Lin Chang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: An international multicenter, prospective, non-interventional, 2-month study characterized acute pain attacks in patients with irritable bowel syndrome (IBS). Methods: Adult patients meeting the Rome III IBS diagnostic criteria with a history of 3 pain attacks per month participated in a survey that captured daily and episodic information regarding IBS symptoms and pain attacks for 2 months. Acute pain attacks were defined as a sudden onset or increase in the intensity of IBS abdominal pain with a minimum intensity of 4 (0-10 scale). Results: The majority (84%) of the 158 patients taking the survey were women with a mean age of 41 years and time since IBS diagnosis of 5 years. The median pain attack frequency was 5.4 attacks per month and was significantly higher in the IBS with diarrhea (IBS-D, 6.4 per month) group vs. the IBS with constipation (4.4 per month) and the IBS with mixed pattern (5.5 per month) groups (P<0.019). The median pain attack duration was 2.8 h and the median intensity score was 7. The majority of pain attacks resulted in defecation (78%), and occurred more often in IBS-D patients than in other subgroups. The majority of pain attacks (63%) interfered with work and/or daily activities. Medication to manage pain attacks was used by 44% of patients during 29% of attacks. Although used by less than half of all patients, medication helped 66% of attacks treated. Conclusions: The frequency of severe pain attacks was 1.4 per week and the majority affected daily activities. However, most of the pain attacks were untreated in IBS patients. Pain attack management is an unmet need of IBS treatment.

Original languageEnglish (US)
Pages (from-to)1299-1307
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume106
Issue number7
DOIs
StatePublished - Jul 2011

Fingerprint

Irritable Bowel Syndrome
Acute Pain
Pain
Defecation
Constipation
Pain Management
Abdominal Pain
Diarrhea

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Characteristics of acute pain attacks in patients with irritable bowel syndrome meeting Rome III criteria. / Hellström, Per M.; Saito Loftus, Yuri Ann; Bytzer, Peter; Tack, Jan; Mueller-Lissner, Stefan; Chang, Lin.

In: American Journal of Gastroenterology, Vol. 106, No. 7, 07.2011, p. 1299-1307.

Research output: Contribution to journalArticle

Hellström, Per M. ; Saito Loftus, Yuri Ann ; Bytzer, Peter ; Tack, Jan ; Mueller-Lissner, Stefan ; Chang, Lin. / Characteristics of acute pain attacks in patients with irritable bowel syndrome meeting Rome III criteria. In: American Journal of Gastroenterology. 2011 ; Vol. 106, No. 7. pp. 1299-1307.
@article{ac20c48e2b92421383c5cf5c1c5609f5,
title = "Characteristics of acute pain attacks in patients with irritable bowel syndrome meeting Rome III criteria",
abstract = "Objectives: An international multicenter, prospective, non-interventional, 2-month study characterized acute pain attacks in patients with irritable bowel syndrome (IBS). Methods: Adult patients meeting the Rome III IBS diagnostic criteria with a history of 3 pain attacks per month participated in a survey that captured daily and episodic information regarding IBS symptoms and pain attacks for 2 months. Acute pain attacks were defined as a sudden onset or increase in the intensity of IBS abdominal pain with a minimum intensity of 4 (0-10 scale). Results: The majority (84{\%}) of the 158 patients taking the survey were women with a mean age of 41 years and time since IBS diagnosis of 5 years. The median pain attack frequency was 5.4 attacks per month and was significantly higher in the IBS with diarrhea (IBS-D, 6.4 per month) group vs. the IBS with constipation (4.4 per month) and the IBS with mixed pattern (5.5 per month) groups (P<0.019). The median pain attack duration was 2.8 h and the median intensity score was 7. The majority of pain attacks resulted in defecation (78{\%}), and occurred more often in IBS-D patients than in other subgroups. The majority of pain attacks (63{\%}) interfered with work and/or daily activities. Medication to manage pain attacks was used by 44{\%} of patients during 29{\%} of attacks. Although used by less than half of all patients, medication helped 66{\%} of attacks treated. Conclusions: The frequency of severe pain attacks was 1.4 per week and the majority affected daily activities. However, most of the pain attacks were untreated in IBS patients. Pain attack management is an unmet need of IBS treatment.",
author = "Hellstr{\"o}m, {Per M.} and {Saito Loftus}, {Yuri Ann} and Peter Bytzer and Jan Tack and Stefan Mueller-Lissner and Lin Chang",
year = "2011",
month = "7",
doi = "10.1038/ajg.2011.78",
language = "English (US)",
volume = "106",
pages = "1299--1307",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Characteristics of acute pain attacks in patients with irritable bowel syndrome meeting Rome III criteria

AU - Hellström, Per M.

AU - Saito Loftus, Yuri Ann

AU - Bytzer, Peter

AU - Tack, Jan

AU - Mueller-Lissner, Stefan

AU - Chang, Lin

PY - 2011/7

Y1 - 2011/7

N2 - Objectives: An international multicenter, prospective, non-interventional, 2-month study characterized acute pain attacks in patients with irritable bowel syndrome (IBS). Methods: Adult patients meeting the Rome III IBS diagnostic criteria with a history of 3 pain attacks per month participated in a survey that captured daily and episodic information regarding IBS symptoms and pain attacks for 2 months. Acute pain attacks were defined as a sudden onset or increase in the intensity of IBS abdominal pain with a minimum intensity of 4 (0-10 scale). Results: The majority (84%) of the 158 patients taking the survey were women with a mean age of 41 years and time since IBS diagnosis of 5 years. The median pain attack frequency was 5.4 attacks per month and was significantly higher in the IBS with diarrhea (IBS-D, 6.4 per month) group vs. the IBS with constipation (4.4 per month) and the IBS with mixed pattern (5.5 per month) groups (P<0.019). The median pain attack duration was 2.8 h and the median intensity score was 7. The majority of pain attacks resulted in defecation (78%), and occurred more often in IBS-D patients than in other subgroups. The majority of pain attacks (63%) interfered with work and/or daily activities. Medication to manage pain attacks was used by 44% of patients during 29% of attacks. Although used by less than half of all patients, medication helped 66% of attacks treated. Conclusions: The frequency of severe pain attacks was 1.4 per week and the majority affected daily activities. However, most of the pain attacks were untreated in IBS patients. Pain attack management is an unmet need of IBS treatment.

AB - Objectives: An international multicenter, prospective, non-interventional, 2-month study characterized acute pain attacks in patients with irritable bowel syndrome (IBS). Methods: Adult patients meeting the Rome III IBS diagnostic criteria with a history of 3 pain attacks per month participated in a survey that captured daily and episodic information regarding IBS symptoms and pain attacks for 2 months. Acute pain attacks were defined as a sudden onset or increase in the intensity of IBS abdominal pain with a minimum intensity of 4 (0-10 scale). Results: The majority (84%) of the 158 patients taking the survey were women with a mean age of 41 years and time since IBS diagnosis of 5 years. The median pain attack frequency was 5.4 attacks per month and was significantly higher in the IBS with diarrhea (IBS-D, 6.4 per month) group vs. the IBS with constipation (4.4 per month) and the IBS with mixed pattern (5.5 per month) groups (P<0.019). The median pain attack duration was 2.8 h and the median intensity score was 7. The majority of pain attacks resulted in defecation (78%), and occurred more often in IBS-D patients than in other subgroups. The majority of pain attacks (63%) interfered with work and/or daily activities. Medication to manage pain attacks was used by 44% of patients during 29% of attacks. Although used by less than half of all patients, medication helped 66% of attacks treated. Conclusions: The frequency of severe pain attacks was 1.4 per week and the majority affected daily activities. However, most of the pain attacks were untreated in IBS patients. Pain attack management is an unmet need of IBS treatment.

UR - http://www.scopus.com/inward/record.url?scp=79960061457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960061457&partnerID=8YFLogxK

U2 - 10.1038/ajg.2011.78

DO - 10.1038/ajg.2011.78

M3 - Article

C2 - 21448146

AN - SCOPUS:79960061457

VL - 106

SP - 1299

EP - 1307

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 7

ER -