Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer

S. Shiovitz, W. K. Copeland, M. N. Passarelli, A. N. Burnett-Hartman, W. M. Grady, J. D. Potter, S. Gallinger, D. D. Buchanan, C. Rosty, A. K. Win, M. Jenkins, Stephen N Thibodeau, R. Haile, J. A. Baron, L. L. Marchand, P. A. Newcomb, Noralane Morey Lindor

Research output: Contribution to journalArticle

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Abstract

Background: Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and 'non-familial' (non-AC1) CRC cases.Methods:From the Colon Cancer Family Registry, FCCTX (n=173), LS (n=303), and non-AC1 (n=9603) CRC cases were identified. Questionnaire-based epidemiologic information and CRC pathologic features were compared across case groups using polytomous logistic regression.Results:Compared with LS, FCCTX cases were less likely to be current (vs never) smokers; have a proximal subsite (vs rectal) tumour; or have mucinous histology, poor differentiation, or tumour-infiltrating lymphocytes. There were no observed differences in co-morbidities or medication usage.Conclusions:FCCTX were less likely to be current tobacco users; other exposures were similar between these groups. Histopathologic differences highly suggestive of LS CRCs do not appear to be shared by FCCTX.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalBritish Journal of Cancer
Volume111
Issue number3
DOIs
StatePublished - Jul 29 2014

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Hereditary Nonpolyposis Colorectal Neoplasms
Colorectal Neoplasms
Colonic Neoplasms
Tumor-Infiltrating Lymphocytes
DNA Mismatch Repair
Rectal Neoplasms
Tobacco
Registries
Histology
Logistic Models

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Shiovitz, S., Copeland, W. K., Passarelli, M. N., Burnett-Hartman, A. N., Grady, W. M., Potter, J. D., ... Lindor, N. M. (2014). Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer. British Journal of Cancer, 111(3), 598-602. https://doi.org/10.1038/bjc.2014.309

Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer. / Shiovitz, S.; Copeland, W. K.; Passarelli, M. N.; Burnett-Hartman, A. N.; Grady, W. M.; Potter, J. D.; Gallinger, S.; Buchanan, D. D.; Rosty, C.; Win, A. K.; Jenkins, M.; Thibodeau, Stephen N; Haile, R.; Baron, J. A.; Marchand, L. L.; Newcomb, P. A.; Lindor, Noralane Morey.

In: British Journal of Cancer, Vol. 111, No. 3, 29.07.2014, p. 598-602.

Research output: Contribution to journalArticle

Shiovitz, S, Copeland, WK, Passarelli, MN, Burnett-Hartman, AN, Grady, WM, Potter, JD, Gallinger, S, Buchanan, DD, Rosty, C, Win, AK, Jenkins, M, Thibodeau, SN, Haile, R, Baron, JA, Marchand, LL, Newcomb, PA & Lindor, NM 2014, 'Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer', British Journal of Cancer, vol. 111, no. 3, pp. 598-602. https://doi.org/10.1038/bjc.2014.309
Shiovitz S, Copeland WK, Passarelli MN, Burnett-Hartman AN, Grady WM, Potter JD et al. Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer. British Journal of Cancer. 2014 Jul 29;111(3):598-602. https://doi.org/10.1038/bjc.2014.309
Shiovitz, S. ; Copeland, W. K. ; Passarelli, M. N. ; Burnett-Hartman, A. N. ; Grady, W. M. ; Potter, J. D. ; Gallinger, S. ; Buchanan, D. D. ; Rosty, C. ; Win, A. K. ; Jenkins, M. ; Thibodeau, Stephen N ; Haile, R. ; Baron, J. A. ; Marchand, L. L. ; Newcomb, P. A. ; Lindor, Noralane Morey. / Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer. In: British Journal of Cancer. 2014 ; Vol. 111, No. 3. pp. 598-602.
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AU - Thibodeau, Stephen N

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N2 - Background: Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and 'non-familial' (non-AC1) CRC cases.Methods:From the Colon Cancer Family Registry, FCCTX (n=173), LS (n=303), and non-AC1 (n=9603) CRC cases were identified. Questionnaire-based epidemiologic information and CRC pathologic features were compared across case groups using polytomous logistic regression.Results:Compared with LS, FCCTX cases were less likely to be current (vs never) smokers; have a proximal subsite (vs rectal) tumour; or have mucinous histology, poor differentiation, or tumour-infiltrating lymphocytes. There were no observed differences in co-morbidities or medication usage.Conclusions:FCCTX were less likely to be current tobacco users; other exposures were similar between these groups. Histopathologic differences highly suggestive of LS CRCs do not appear to be shared by FCCTX.

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