Changing Epidemiology of Hepatitis B in a U.S. Community

W. Ray Kim, Joanne T. Benson, Terry M Therneau, Heidi A. Torgerson, Barbara P. Yawn, L. Joseph Melton

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Despite a reduction in newly acquired hepatitis B virus (HBV) infections since the mid-1980s, HBV remains an important cause of liver disease in the U.S. We report the prevalence of chronic HBV infection in a U.S. community and describe demographic and clinical characteristics. The Rochester Epidemiology Project records healthcare encounters of residents of Olmsted County, Minnesota. For all cases with a potential diagnosis of hepatitis B in this database, complete medical records were reviewed to identify subjects who met the inclusion criteria, i.e., a clinician diagnosis of chronic HBV infection and a laboratory record of positive hepatitis B surface antigen (HBsAg). There were 191 residents with chronic HBV infection in the community, consisting of 53% Asian, 29% African, 13% Caucasian, and 5% other or unknown race. The overall age- and sex-adjusted prevalence of HBV in this community was 0.15% in 2000. The race-specific prevalence was highest among Asians (2.1%), followed by African Americans (1.9%). The prevalence among Caucasians was 0.02%. Overall, 86% were born outside the U.S., 98% of whom were non-Caucasian. A total of 131 residents were tested for HBV replicative status, of whom 27% had viral replication. Of those tested for aminotransferases (n = 184), 28% had an abnormal value at least once. In a multivariable regression analysis, replicative status was the most influential (odds ratio [OR] = 5.98, P < .01) factor associated with abnormal aminotransferase values, followed by male gender (OR = 3.69) and age greater than 40 years (OR = 2.32 per decade). In conclusion, in this Midwestern community, chronic HBV infection was predominantly seen in immigrants from endemic parts of the world.

Original languageEnglish (US)
Pages (from-to)811-816
Number of pages6
JournalHepatology
Volume39
Issue number3
DOIs
StatePublished - Mar 2004

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Hepatitis B
Hepatitis B virus
Epidemiology
Virus Diseases
Chronic Hepatitis B
Odds Ratio
Transaminases
Hepatitis B Surface Antigens
African Americans
Medical Records
Liver Diseases
Regression Analysis
Demography
Databases
Delivery of Health Care

ASJC Scopus subject areas

  • Hepatology

Cite this

Kim, W. R., Benson, J. T., Therneau, T. M., Torgerson, H. A., Yawn, B. P., & Melton, L. J. (2004). Changing Epidemiology of Hepatitis B in a U.S. Community. Hepatology, 39(3), 811-816. https://doi.org/10.1002/hep.20098

Changing Epidemiology of Hepatitis B in a U.S. Community. / Kim, W. Ray; Benson, Joanne T.; Therneau, Terry M; Torgerson, Heidi A.; Yawn, Barbara P.; Melton, L. Joseph.

In: Hepatology, Vol. 39, No. 3, 03.2004, p. 811-816.

Research output: Contribution to journalArticle

Kim, WR, Benson, JT, Therneau, TM, Torgerson, HA, Yawn, BP & Melton, LJ 2004, 'Changing Epidemiology of Hepatitis B in a U.S. Community', Hepatology, vol. 39, no. 3, pp. 811-816. https://doi.org/10.1002/hep.20098
Kim WR, Benson JT, Therneau TM, Torgerson HA, Yawn BP, Melton LJ. Changing Epidemiology of Hepatitis B in a U.S. Community. Hepatology. 2004 Mar;39(3):811-816. https://doi.org/10.1002/hep.20098
Kim, W. Ray ; Benson, Joanne T. ; Therneau, Terry M ; Torgerson, Heidi A. ; Yawn, Barbara P. ; Melton, L. Joseph. / Changing Epidemiology of Hepatitis B in a U.S. Community. In: Hepatology. 2004 ; Vol. 39, No. 3. pp. 811-816.
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