Changes of the human gut microbiome induced by a fermented milk product

Patrick Veiga, Nicolas Pons, Anurag Agrawal, Raish Oozeer, Denis Guyonnet, Rémi Brazeilles, Jean Michel Faurie, Johan E.T. Van Hylckama Vlieg, Lesley A. Houghton, Peter J. Whorwell, S. Dusko Ehrlich, Sean P. Kennedy

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

The gut microbiota (GM) consists of resident commensals and transient microbes conveyed by the diet but little is known about the role of the latter on GM homeostasis. Here we show, by a conjunction of quantitative metagenomics, in silico genome reconstruction and metabolic modeling, that consumption of a fermented milk product containing dairy starters and Bifidobacterium animalis potentiates colonic short chain fatty acids production and decreases abundance of a pathobiont Bilophila wadsworthia compared to a milk product in subjects with irritable bowel syndrome (IBS, n = 28). The GM changes parallel improvement of IBS state, suggesting a role of the fermented milk bacteria in gut homeostasis. Our data challenge the view that microbes ingested with food have little impact on the human GM functioning and rather provide support for beneficial health effects.

Original languageEnglish (US)
Article number6328
JournalScientific reports
Volume4
DOIs
StatePublished - Sep 11 2014

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Changes of the human gut microbiome induced by a fermented milk product'. Together they form a unique fingerprint.

  • Cite this

    Veiga, P., Pons, N., Agrawal, A., Oozeer, R., Guyonnet, D., Brazeilles, R., Faurie, J. M., Van Hylckama Vlieg, J. E. T., Houghton, L. A., Whorwell, P. J., Ehrlich, S. D., & Kennedy, S. P. (2014). Changes of the human gut microbiome induced by a fermented milk product. Scientific reports, 4, [6328]. https://doi.org/10.1038/srep06328