Changes in screening, prognosis and therapy for esophageal adenocarcinoma in Barrett's esophagus

Yutaka Tomizawa, Kenneth Ke Ning Wang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Purpose of review: Significant changes in concepts of managing Barrett's esophagus have led to change in the recommendations concerning screening, surveillance, biomarkers, and therapies in this condition over the past several years. We summarize the important changes in this regard. Recent findings: Narrow band imaging and esophageal capsule endoscopy are alternative methods to screen for Barrett's esophagus. Narrow band imaging provides clear visualization of the mucosal pit patterns and vascular patterns, which improve the diagnostic value for specialized intestinal mataplasia. Esophageal capsule endoscopy is a new potential tool that allows a direct noninvasive visualization of esophagus. Research efforts are currently directed towards risk stratification of patients and biomarkers have been developed to predict development of esophageal adenocarcinoma. Recent studies have reported that frequent loss of heterozygosity (LOH) as well as allelic imbalances in chromosomes in esophageal adenocarcinoma. Fluorescent in-situ hybridization technique, which uses fluorescently labeled DNA probes to detect chromosomal alterations in cells, obtained from cytology specimens has been developed. It showed more sensitive and specific for abnormalities than PCR based techniques. Currently, many studies support the concept of endoscopic elimination of dysplastic lesions in the esophagus by a mucosal ablation therapy. Photodynamic therapy and radiofrequency ablation are recently developed, emerging techniques. Summary: Recent advances in screening; prognostication and therapy for esophageal adenocarcinoma in Barrett's esophagus have brought a significant new insight in clinical practices and will eventually ensure better patients outcomes.

Original languageEnglish (US)
Pages (from-to)358-365
Number of pages8
JournalCurrent Opinion in Gastroenterology
Volume25
Issue number4
DOIs
StatePublished - Jul 2009

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Keywords

  • Esophageal capsule endoscopy
  • Fluorescent in-situ hybridization
  • Narrow band imaging
  • Photodynamic therapy
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Gastroenterology

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