Changes in plasma concentrations of atrial natriuretic peptide during exchange transfusion in premature infants

Andras Khoor, T. Tulassay, M. Bald, W. Rascher

Research output: Contribution to journalArticle

4 Scopus citations


Plasma concentrations of atrial natriuretic peptide (ANP) and hemodynamic parameters were investigated in five premature infants undergoing exchange transfusion. Baseline values of ANP were 51.7±21.2 fmol/ml. Volume depletion by withdrawal of 10 ml blood did not cause changes in systolic blood pressure (79.4±4.3 vs. 71.4±5.6 mmHg) and heart rate (115±5.2 vs. 115±2.4 b/min). ANP levels in plasma remained unaltered (53.4±24.9 fmol/ml). Replacement of 10 ml blood increased central venous pressure by 33% and ANP concentration in the plasma by nearly 30%, while heart rate and blood pressure remained unchanged. Our data indicate that the heart of the premature infant responded to acute blood replacement with increased ANP-release, while blood removal appeared not to influence hormone regulation.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalActa Paediatrica Scandinavica
Issue number5
StatePublished - 1990
Externally publishedYes



  • atrial natriuretic peptide
  • central nervous pressure
  • exchange transfusion
  • premature neonates

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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