Abstract
Plasma concentrations of atrial natriuretic peptide (ANP) and hemodynamic parameters were investigated in five premature infants undergoing exchange transfusion. Baseline values of ANP were 51.7±21.2 fmol/ml. Volume depletion by withdrawal of 10 ml blood did not cause changes in systolic blood pressure (79.4±4.3 vs. 71.4±5.6 mmHg) and heart rate (115±5.2 vs. 115±2.4 b/min). ANP levels in plasma remained unaltered (53.4±24.9 fmol/ml). Replacement of 10 ml blood increased central venous pressure by 33% and ANP concentration in the plasma by nearly 30%, while heart rate and blood pressure remained unchanged. Our data indicate that the heart of the premature infant responded to acute blood replacement with increased ANP-release, while blood removal appeared not to influence hormone regulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 513-517 |
| Number of pages | 5 |
| Journal | Acta Paediatrica Scandinavica |
| Volume | 79 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1990 |
Keywords
- atrial natriuretic peptide
- central nervous pressure
- exchange transfusion
- premature neonates
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health