TY - JOUR
T1 - Changes in cytokines during treatment of elderly, hospitalized psychiatric patients – a naturalistic study
AU - Bugge, Erlend
AU - Wynn, Rolf
AU - Mollnes, Tom Eirik
AU - Reitan, Solveig Klæbo
AU - Lapid, Maria I.
AU - Grønli, Ole Kristian
N1 - Funding Information:
This project is financed by the Northern Norway Regional Health Authority , grant number PFP1298–16 . The recipients are EB and OKG. The funding institution had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2019 The Authors
PY - 2019/10
Y1 - 2019/10
N2 - Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now.
AB - Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now.
KW - Cytokine
KW - Depression
KW - Gerontopsychiatric
KW - Neuroimmunology
KW - Neuroinflammation
KW - Psychogeriatric
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U2 - 10.1016/j.psyneuen.2019.06.014
DO - 10.1016/j.psyneuen.2019.06.014
M3 - Article
C2 - 31276906
AN - SCOPUS:85068190190
SN - 0306-4530
VL - 108
SP - 135
EP - 139
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -