Changes in central artery blood pressure and wave reflection during a cold pressor test in young adults

Darren P. Casey, Randy W. Braith, Gary L. Pierce

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The relative contribution of sympathetic nervous system (SNS)-induced increase in peripheral vascular resistance on central artery blood pressure (BP) and aortic wave reflection (augmentation index; AIx) is not completely understood. Central BP and wave reflection characteristics were measured using radial artery applanation tonometry before, during a 3-min cold pressor test (CPT), and 90 and 180-s post-CPT in 15 young, healthy adults (25 ± 1 years). The CPT resulted in a greater magnitude of change in the estimated aortic systolic <31 vs. 23%, P < 0.05) and pulse (31 vs. 13%, P < 0.05) BP compared with the change in brachial artery BP. Additionally, the CPT resulted in an increased mean arterial pressure (MAP) (P < 0.05) and AIx (10 ± 2 vs. 26 ± 2%, P < 0.05). The change in MAP during the CPT was correlated to the change in AIx (r = 0.73, P < 0.01) and inversely related to roundtrip duration of the reflected wave to the periphery and back (r = -0.57, P < 0.05). The present study suggests that cold pressor testing results in a significant increase in arterial wave reflection intensity, possibly due to an increased MAP. However, the greater increase in systolic and pulse BP in the central compared with the peripheral circulation suggests that increased central artery wave reflection intensity contributes to increased left ventricular myocardial oxygen demand during CPT-induced hypertension.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalEuropean Journal of Applied Physiology
Volume103
Issue number5
DOIs
StatePublished - Jul 2008

Fingerprint

Young Adult
Arteries
Blood Pressure
Arterial Pressure
Vascular Resistance
Radial Artery
Brachial Artery
Sympathetic Nervous System
Manometry
Pulse
Oxygen
Hypertension

Keywords

  • Blood pressure
  • Sympathetic nervous system
  • Wave reflection

ASJC Scopus subject areas

  • Physiology
  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Changes in central artery blood pressure and wave reflection during a cold pressor test in young adults. / Casey, Darren P.; Braith, Randy W.; Pierce, Gary L.

In: European Journal of Applied Physiology, Vol. 103, No. 5, 07.2008, p. 539-543.

Research output: Contribution to journalArticle

Casey, Darren P. ; Braith, Randy W. ; Pierce, Gary L. / Changes in central artery blood pressure and wave reflection during a cold pressor test in young adults. In: European Journal of Applied Physiology. 2008 ; Vol. 103, No. 5. pp. 539-543.
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