Challenges to Randomized Trials in Adult and Congenital Cardiac and Thoracic Surgery

Mario Gaudino, Joanna Chikwe, Emilia Bagiella, Stephen Fremes, David R. Jones, Bryan Meyers, Jane W. Newburger, Richard G. Ohye, Peter Sassalos, Dennis Wigle, Antonino Di Franco

Research output: Contribution to journalReview articlepeer-review

Abstract

Randomized trials in surgery face additional challenges compared with those in medicine. Some of the challenges are intrinsic to the nature of the field (eg, issues with blinding, learning curve and surgeons’ experience, and difficulties in defining the appropriate timing for comparative trials). Other issues are related to the surgical culture, the attitude of surgeons toward randomized trials, and the lack of support by professional and national bodies. In this review, a group of investigators with experience in trials in congenital and adult cardiac and thoracic surgery discusses the key issues with surgical trials and suggests potential solutions.

Original languageEnglish (US)
JournalAnnals of Thoracic Surgery
DOIs
StateAccepted/In press - 2021

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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