Challenges in the Treatment of Restless Legs Syndrome: A Case Report

Audrey Umbreit, Shirshendu Sinha, Bhanu Prakash Kolla, Meghna P. Mansukhani

Research output: Contribution to journalArticlepeer-review


Treatment resistant restless legs syndrome (RLS) in the setting of psychiatric comorbidities can be difficult to manage. Our patient is a 69-year-old Caucasian gentleman with bipolar disorder type I, unspecified anxiety disorder, obstructive sleep apnea (OSA), and treatment-refractory RLS. At initial presentation, the patient’s prescribed medication regimen included fluoxetine 40 mg daily, gabapentin 800 mg in the morning and 3200 mg at bedtime, pramipexole 0.375 mg daily, lamotrigine 200 mg daily, trazodone 200 mg at bedtime, and temazepam 15 to 30 mg as needed for insomnia and RLS. Over the course of nearly 4 years, treatment interventions for this patient’s RLS included: cognitive behavioral therapy for insomnia, discontinuation of exacerbating medications, switching dopamine agonists, use of pregabalin and iron supplement. This report demonstrates a challenging case of RLS in the setting of psychiatric comorbidities, development of augmentation, and polypharmacy.

Original languageEnglish (US)
JournalJournal of Primary Care and Community Health
StatePublished - 2021


  • case report
  • medications
  • mood disorder
  • psychiatry
  • restless legs

ASJC Scopus subject areas

  • Community and Home Care
  • Public Health, Environmental and Occupational Health


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