CFTR, a channel with the structure of a transporter

John R. Riordan, Xiu Bao Chang

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to a superfamily of active transport molecules. However, when expressed in a wide variety of heterologous cell systems and when purified to homogeneity and reconstituted in planar lipid bilayers, it exhibits low conductance chloride channel activity. We postulate that the active transport capability of the molecule has been adapted to provide very stringent metabolic control of this channel which is responsible for chloride secretion and hydration of wet epithelial surfaces.

Original languageEnglish (US)
Pages (from-to)221-222
Number of pages2
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1101
Issue number2
DOIs
StatePublished - 1992

Keywords

  • Cystic fibrosis
  • Cystic fibrosis transmembrane conductance regulator
  • Membrane transport

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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