Cervicography screening for cervical cancer among 8460 women in a high- risk population

D. L. Schneider, R. Herrero, C. Bratti, M. D. Greenberg, A. Hildesheim, M. E. Sherman, J. Morales, M. L. Hutchinson, T. V. Sedlacek, A. Lorincz, L. Mango, S. Wacholder, M. Alfaro, M. Schiffman

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

OBJECTIVE: Cervicography was evaluated as a primary screening method for cervical cancer. STUDY DESIGN: Cervigrams of 8460 women were taken on enrollment into a population-based study of cervical neoplasia. Cervicography results were corn pared with a referent diagnosis determined by histologic analysis and 3 cytologic tests, and with the performance of conventional cytologic evaluation. RESULTS: Cervicography identified all 11 cancers, whereas cytologic testing missed 1. Cervicography yielded sensitivities for detecting high-grade squamous intraepithelial lesions or cancer of 49.3% overall (specificity, 95.0%), 54.6% in women younger than 50 years of age, and 26.9% in women 50 years of age and older. Cytologic testing yielded sensitivities for detecting high-grade squamous intraepithelial lesions or cancer of 77.2% overall (specificity, 94.2%), 75.5% in women younger than 50 years of age, and 84.6% in women 50 years of age and older. CONCLUSIONS: Cytologic testing performed better than cervicography for the detection of high-grade squamous intraepithelial lesions. Cervicography performed marginally better than cytologic testing for the detection of invasive cervical cancer. Cervicography is not recommended for postmenopausal women.

Original languageEnglish (US)
Pages (from-to)290-298
Number of pages9
JournalAmerican journal of obstetrics and gynecology
Volume180
Issue number2 I
DOIs
StatePublished - 1999

Keywords

  • Cervical cancer
  • Cervicography
  • Cervix
  • Screening
  • Visual

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Schneider, D. L., Herrero, R., Bratti, C., Greenberg, M. D., Hildesheim, A., Sherman, M. E., Morales, J., Hutchinson, M. L., Sedlacek, T. V., Lorincz, A., Mango, L., Wacholder, S., Alfaro, M., & Schiffman, M. (1999). Cervicography screening for cervical cancer among 8460 women in a high- risk population. American journal of obstetrics and gynecology, 180(2 I), 290-298. https://doi.org/10.1016/S0002-9378(99)70202-4