Cervical dorsal rhizotomy (CDR) enhances long term facilitation of respiratory motor output in rats

R. Kinkead, W. Z. Zhan, Y.s. Prakash, K. B. Bach, Gary C Sieck, G. S. Mitchell

Research output: Contribution to journalArticle

Abstract

Long term facilitation (LTF) is a long lasting, serotonin-dependent enhancement of respiratory motor output following episodic hypoxia. Because bilateral CDR increases serotonergic innervation of phrenic motoneurons (Prakash et al., ibid), we hypothesized that CDR (C3-C5) increases LTF in phrenic (spinal), but not hypoglossal (brainstem) motor output. 28 days before studies, surgery was performed on two groups of adult male rats (CDR and sham-operated, both N =6). LTF was assessed in anesthetized, vagotomized and pump ventilated rats that were exposed to three, 5 min episodes of isocapnic hypoxia (FIO2=0.11), separated by 5 min hyperoxic intervals (FIO2=0.5). LTF in both phrenic (p=0.001) and hypoglossal (p=0.047) respiratory motor output was greater in CDR vs sham operated rats. The results suggest that enhanced serotonergic modulation: 1) increases LTF in both spinal (phrenic) and brainstem (hypoglossal) respiratory motor output following CDR, and 2) overrides decreased excitability due to phrenic motoneuron enlargement following CDR (Zhan et al., ibid). We speculate that CDR enhances serotonin terminal density in all respiratory motor nuclei innervated by the same raphe neurons.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Rhizotomy
Rats
Diaphragm
rats
brain stem
motor neurons
serotonin
hypoxia
Serotonin
Motor Neurons
Brain Stem
innervation
pumps
Surgery
Neurons
surgery
neurons
Modulation
Pumps

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Kinkead, R., Zhan, W. Z., Prakash, Y. S., Bach, K. B., Sieck, G. C., & Mitchell, G. S. (1997). Cervical dorsal rhizotomy (CDR) enhances long term facilitation of respiratory motor output in rats. FASEB Journal, 11(3).

Cervical dorsal rhizotomy (CDR) enhances long term facilitation of respiratory motor output in rats. / Kinkead, R.; Zhan, W. Z.; Prakash, Y.s.; Bach, K. B.; Sieck, Gary C; Mitchell, G. S.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Kinkead, R, Zhan, WZ, Prakash, YS, Bach, KB, Sieck, GC & Mitchell, GS 1997, 'Cervical dorsal rhizotomy (CDR) enhances long term facilitation of respiratory motor output in rats', FASEB Journal, vol. 11, no. 3.
Kinkead, R. ; Zhan, W. Z. ; Prakash, Y.s. ; Bach, K. B. ; Sieck, Gary C ; Mitchell, G. S. / Cervical dorsal rhizotomy (CDR) enhances long term facilitation of respiratory motor output in rats. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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