Cerebrovascular reactivity to hypercapnia is unimpaired in breath-hold divers

Vladimir Ivancev, Ivan Palada, Zoran Valic, Ante Obad, Darija Bakovic, Niki M. Dietz, Michael J. Joyner, Zeljko Dujic

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Hypercapnic cerebrovascular reactivity is decreased in obstructive sleep apnoea and congestive heart disease perhaps as a result of repeated apnoeas. To test the hypothesis that repeated apnoeas blunt cerebrovascular reactivity to hypercapnia, we studied breath hold divers and determined cerebrovascular reactivity by measuring changes in middle cerebral artery velocity (MCAV, cm s-1) per mmHg change in end-tidal partial pressure of CO2 (PET,CO2) in response to two hyperoxic hypercapnia rebreathing manoeuvres (modified Read protocol) in elite breath-hold divers (BHD, n = 7) and non-divers (ND, n = 7). In addition, ventilation and central (beat-to-beat stroke volume measurement with Modelflow technique) haemodynamics were determined. Ventilatory responses to hypercapnia were blunted in BHD versus ND largely due to lower breathing frequency. Cerebrovascular reactivity did not differ between groups (3.7 ± 1.4 versus 3.4 ± 1.3% mmHg-1 PET,CO2 in BHD and ND, respectively; P = 0.90) and the same was found for cerebral vascular resistance and MCAV recovery to baseline after termination of the CO2 challenge. Cardiovascular parameters were not changed significantly during rebreathing in either group, except for a small increase in mean arterial pressure for both groups. Our findings indicate that the regulation of the cerebral circulation in response to hypercapnia is intact in elite breath-hold divers, potentially as a protective mechanism against the chronic intermittent cerebral hypoxia and/or hypercapnia that occurs during breath-hold diving. These data also suggest that factors other than repeated apnoeas contribute to the blunting of cerebrovascular reactivity in conditions like sleep apnoea.

Original languageEnglish (US)
Pages (from-to)723-730
Number of pages8
JournalJournal of Physiology
Volume582
Issue number2
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Physiology

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