Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women with Histories of Preeclampsia

Jill N. Barnes, Ronée E. Harvey, Kathleen B. Miller, Muthuvel Jayachandran, Katherine R. Malterer, Brian D. Lahr, Kent R Bailey, Michael Joseph Joyner, Virginia M Miller

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cerebrovascular reactivity (CVR) is reduced in patients with cognitive decline. Women with a history of preeclampsia are at increased risk for cognitive decline. This study examined an association between pregnancy history and CVR using a subgroup of 40 age- and parity-matched pairs of women having histories of preeclampsia (n=27) or normotensive pregnancy (n=29) and the association of activated blood elements with CVR. Middle cerebral artery velocity was measured by Doppler ultrasound before and during hypercapnia to assess CVR. Thirty-eight parameters of blood cellular elements, microvesicles, and cell-cell interactions measured in venous blood were assessed for association with CVR using principal component analysis. Middle cerebral artery velocity was lower in the preeclampsia compared with the normotensive group at baseline (63±4 versus 73±3 cm/s; P=0.047) and during hypercapnia (P=0.013-0.056). CVR was significantly lower in the preeclampsia compared with the normotensive group (2.1±1.3 versus 2.9±1.1 cm·s·mm Hg; P=0.009). Globally, the association of the 7 identified principal components with preeclampsia (P=0.107) and with baseline middle cerebral artery velocity (P=0.067) did not reach statistical significance. The interaction between pregnancy history and principal components with respect to CVR (P=0.084) was driven by a nominally significant interaction between preeclampsia and the individual principal component defined by blood elements, platelet aggregation, and interactions of platelets with monocytes and granulocytes (P=0.008). These results suggest that having a history of preeclampsia negatively affects the cerebral circulation years beyond the pregnancy and that this effect was associated with activated blood elements.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalHypertension
Volume71
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Pre-Eclampsia
Blood Vessels
Middle Cerebral Artery
Reproductive History
Hypercapnia
Cerebrovascular Circulation
Blood Platelets
Doppler Ultrasonography
Pregnancy
Parity
Principal Component Analysis
Platelet Aggregation
Granulocytes
Cell Communication
Monocytes

Keywords

  • hypercapnia
  • middle cerebral artery
  • monocytes
  • platelet aggregation
  • pregnancy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women with Histories of Preeclampsia. / Barnes, Jill N.; Harvey, Ronée E.; Miller, Kathleen B.; Jayachandran, Muthuvel; Malterer, Katherine R.; Lahr, Brian D.; Bailey, Kent R; Joyner, Michael Joseph; Miller, Virginia M.

In: Hypertension, Vol. 71, No. 1, 01.01.2018, p. 110-117.

Research output: Contribution to journalArticle

Barnes, Jill N. ; Harvey, Ronée E. ; Miller, Kathleen B. ; Jayachandran, Muthuvel ; Malterer, Katherine R. ; Lahr, Brian D. ; Bailey, Kent R ; Joyner, Michael Joseph ; Miller, Virginia M. / Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women with Histories of Preeclampsia. In: Hypertension. 2018 ; Vol. 71, No. 1. pp. 110-117.
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