Cerebrovascular mental stress reactivity is impaired in hypertension

Tasneem Zehra Naqvi, Hanh K. Hyuhn

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. Brachial artery reactivity in response to shear stress is altered in subjects with hypertension. Since endothelial dysfunction is generalized, we hypothesized that carotid artery (CA) reactivity would also be altered in hypertension. Purpose. To compare (CA endothelium-dependent vasodilation in response to mental stress in normal and hypertensive subjects. Methods. We evaluated CA reactivity to mental stress in 10 young healthy human volunteers (aged 23 4 years), 20 older healthy volunteers (aged 49 11 years) and in 28 patients with essential hypertension (aged 51 13 years). In 10 healthy volunteers and 12 hypertensive subjects, middle cerebral artery (MCA) PW transcranial Doppler was performed before and 3 minutes after mental stress. Results. Mental stress by Stroop color word conflict, math or anger recall tests caused CA vasodilation in young healthy subjects (0.61 0.06 to 0.65 0.07 cm, p < 0.05) and in older healthy subjects (0.63 0.06 to 0.66 0.07 cm, p < 0.05), whereas no CA vasodilation occurred in hypertensive subjects (0.69 0.06 to 0.68 0.07 cm; p, NS). CA blood flow in response to mental stress increased in young healthy subjects (419 134 to 541 209 ml, p < 0.01 vs. baseline) and in older healthy subjects (351 114 to 454 136 ml, p < 0.01 vs. baseline) whereas no change in blood flow (444 143 vs. 458 195 ml; p, 0.59) occurred in hypertensive subjects. There was no difference in the CA response to nitroglycerin in healthy and hypertensive subjects. Mental stress caused a significant increase in baseline to peak MCA systolic (84 22 to 95 22 cm/s, p < 0.05), diastolic (42 12 to 49 14 cm/s, p < 0.05) as well as mean (30 13 to 39 13 cm/s, p < 0.05) PW Doppler velocities in normal subjects, whereas no change in systolic (70 18 to 73 22 cm/s, p < 0.05), diastolic (34 14 to 37 14 cm/s, p = ns) or mean velocities (25 9 to 26 9 cm/s, p = ns) occurred in hypertensive subjects, despite a similar increase in heart rate and blood pressure in response to mental stress in both groups. Conclusion. Mental stress produces CA vasodilation and is accompanied by an increase in CA and MCA blood flow in healthy subjects. This mental stress induced CA vasodilation and flow reserve is attenuated in subjects with hypertension and may reflect cerebral vascular endothelial dysfunction. Assessment of mental stress induced CA reactivity by ultrasound is a novel method for assessing the impact of hypertension on cerebrovascular endothelial function and blood flow reserve.

Original languageEnglish (US)
Article number32
JournalCardiovascular Ultrasound
Volume7
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

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Carotid Arteries
Hypertension
Healthy Volunteers
Vasodilation
Middle Cerebral Artery
Cerebrovascular Circulation
Brachial Artery
Nitroglycerin
Anger
Endothelium
Blood Vessels
Color
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Cerebrovascular mental stress reactivity is impaired in hypertension. / Naqvi, Tasneem Zehra; Hyuhn, Hanh K.

In: Cardiovascular Ultrasound, Vol. 7, No. 1, 32, 2009.

Research output: Contribution to journalArticle

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abstract = "Background. Brachial artery reactivity in response to shear stress is altered in subjects with hypertension. Since endothelial dysfunction is generalized, we hypothesized that carotid artery (CA) reactivity would also be altered in hypertension. Purpose. To compare (CA endothelium-dependent vasodilation in response to mental stress in normal and hypertensive subjects. Methods. We evaluated CA reactivity to mental stress in 10 young healthy human volunteers (aged 23 4 years), 20 older healthy volunteers (aged 49 11 years) and in 28 patients with essential hypertension (aged 51 13 years). In 10 healthy volunteers and 12 hypertensive subjects, middle cerebral artery (MCA) PW transcranial Doppler was performed before and 3 minutes after mental stress. Results. Mental stress by Stroop color word conflict, math or anger recall tests caused CA vasodilation in young healthy subjects (0.61 0.06 to 0.65 0.07 cm, p < 0.05) and in older healthy subjects (0.63 0.06 to 0.66 0.07 cm, p < 0.05), whereas no CA vasodilation occurred in hypertensive subjects (0.69 0.06 to 0.68 0.07 cm; p, NS). CA blood flow in response to mental stress increased in young healthy subjects (419 134 to 541 209 ml, p < 0.01 vs. baseline) and in older healthy subjects (351 114 to 454 136 ml, p < 0.01 vs. baseline) whereas no change in blood flow (444 143 vs. 458 195 ml; p, 0.59) occurred in hypertensive subjects. There was no difference in the CA response to nitroglycerin in healthy and hypertensive subjects. Mental stress caused a significant increase in baseline to peak MCA systolic (84 22 to 95 22 cm/s, p < 0.05), diastolic (42 12 to 49 14 cm/s, p < 0.05) as well as mean (30 13 to 39 13 cm/s, p < 0.05) PW Doppler velocities in normal subjects, whereas no change in systolic (70 18 to 73 22 cm/s, p < 0.05), diastolic (34 14 to 37 14 cm/s, p = ns) or mean velocities (25 9 to 26 9 cm/s, p = ns) occurred in hypertensive subjects, despite a similar increase in heart rate and blood pressure in response to mental stress in both groups. Conclusion. Mental stress produces CA vasodilation and is accompanied by an increase in CA and MCA blood flow in healthy subjects. This mental stress induced CA vasodilation and flow reserve is attenuated in subjects with hypertension and may reflect cerebral vascular endothelial dysfunction. Assessment of mental stress induced CA reactivity by ultrasound is a novel method for assessing the impact of hypertension on cerebrovascular endothelial function and blood flow reserve.",
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AB - Background. Brachial artery reactivity in response to shear stress is altered in subjects with hypertension. Since endothelial dysfunction is generalized, we hypothesized that carotid artery (CA) reactivity would also be altered in hypertension. Purpose. To compare (CA endothelium-dependent vasodilation in response to mental stress in normal and hypertensive subjects. Methods. We evaluated CA reactivity to mental stress in 10 young healthy human volunteers (aged 23 4 years), 20 older healthy volunteers (aged 49 11 years) and in 28 patients with essential hypertension (aged 51 13 years). In 10 healthy volunteers and 12 hypertensive subjects, middle cerebral artery (MCA) PW transcranial Doppler was performed before and 3 minutes after mental stress. Results. Mental stress by Stroop color word conflict, math or anger recall tests caused CA vasodilation in young healthy subjects (0.61 0.06 to 0.65 0.07 cm, p < 0.05) and in older healthy subjects (0.63 0.06 to 0.66 0.07 cm, p < 0.05), whereas no CA vasodilation occurred in hypertensive subjects (0.69 0.06 to 0.68 0.07 cm; p, NS). CA blood flow in response to mental stress increased in young healthy subjects (419 134 to 541 209 ml, p < 0.01 vs. baseline) and in older healthy subjects (351 114 to 454 136 ml, p < 0.01 vs. baseline) whereas no change in blood flow (444 143 vs. 458 195 ml; p, 0.59) occurred in hypertensive subjects. There was no difference in the CA response to nitroglycerin in healthy and hypertensive subjects. Mental stress caused a significant increase in baseline to peak MCA systolic (84 22 to 95 22 cm/s, p < 0.05), diastolic (42 12 to 49 14 cm/s, p < 0.05) as well as mean (30 13 to 39 13 cm/s, p < 0.05) PW Doppler velocities in normal subjects, whereas no change in systolic (70 18 to 73 22 cm/s, p < 0.05), diastolic (34 14 to 37 14 cm/s, p = ns) or mean velocities (25 9 to 26 9 cm/s, p = ns) occurred in hypertensive subjects, despite a similar increase in heart rate and blood pressure in response to mental stress in both groups. Conclusion. Mental stress produces CA vasodilation and is accompanied by an increase in CA and MCA blood flow in healthy subjects. This mental stress induced CA vasodilation and flow reserve is attenuated in subjects with hypertension and may reflect cerebral vascular endothelial dysfunction. Assessment of mental stress induced CA reactivity by ultrasound is a novel method for assessing the impact of hypertension on cerebrovascular endothelial function and blood flow reserve.

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