Cerebral Fat Embolism: Recognition, Complications, and Prognosis

Daniel Agustín Godoy, Mario Di Napoli, Alejandro Rabinstein

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Fat embolism syndrome (FES) is a rare syndrome caused by embolization of fat particles into multiple organs including the brain. It typically manifests with petechial rash, deteriorating mental status, and progressive respiratory insufficiency, usually occurring within 24–48 h of trauma with long-bone fractures or an orthopedic surgery. The diagnosis of FES is based on clinical and imaging findings, but requires exclusion of alternative diagnoses. Although there is no specific treatment for FES, prompt recognition is important because it can avoid unnecessary interventions and clarify prognosis. Patients with severe FES can become critically ill, but even comatose patients with respiratory failure may recover favorably. Prophylactic measures, such as early stabilization of fractures and certain intraoperative techniques, may help decrease the incidence and severity of FES.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalNeurocritical Care
DOIs
StateAccepted/In press - Sep 20 2017

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Keywords

  • Cerebral fat embolism
  • Coma
  • Fat embolism syndrome
  • Magnetic resonance imaging
  • Paroxysmal sympathetic hyperactivity

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Clinical Neurology

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