TY - JOUR
T1 - Cerebral Fat Embolism
T2 - Recognition, Complications, and Prognosis
AU - Godoy, Daniel Agustín
AU - Di Napoli, Mario
AU - Rabinstein, Alejandro A.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Fat embolism syndrome (FES) is a rare syndrome caused by embolization of fat particles into multiple organs including the brain. It typically manifests with petechial rash, deteriorating mental status, and progressive respiratory insufficiency, usually occurring within 24–48 h of trauma with long-bone fractures or an orthopedic surgery. The diagnosis of FES is based on clinical and imaging findings, but requires exclusion of alternative diagnoses. Although there is no specific treatment for FES, prompt recognition is important because it can avoid unnecessary interventions and clarify prognosis. Patients with severe FES can become critically ill, but even comatose patients with respiratory failure may recover favorably. Prophylactic measures, such as early stabilization of fractures and certain intraoperative techniques, may help decrease the incidence and severity of FES.
AB - Fat embolism syndrome (FES) is a rare syndrome caused by embolization of fat particles into multiple organs including the brain. It typically manifests with petechial rash, deteriorating mental status, and progressive respiratory insufficiency, usually occurring within 24–48 h of trauma with long-bone fractures or an orthopedic surgery. The diagnosis of FES is based on clinical and imaging findings, but requires exclusion of alternative diagnoses. Although there is no specific treatment for FES, prompt recognition is important because it can avoid unnecessary interventions and clarify prognosis. Patients with severe FES can become critically ill, but even comatose patients with respiratory failure may recover favorably. Prophylactic measures, such as early stabilization of fractures and certain intraoperative techniques, may help decrease the incidence and severity of FES.
KW - Cerebral fat embolism
KW - Coma
KW - Fat embolism syndrome
KW - Magnetic resonance imaging
KW - Paroxysmal sympathetic hyperactivity
UR - http://www.scopus.com/inward/record.url?scp=85029585585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029585585&partnerID=8YFLogxK
U2 - 10.1007/s12028-017-0463-y
DO - 10.1007/s12028-017-0463-y
M3 - Review article
C2 - 28932982
AN - SCOPUS:85029585585
SN - 1541-6933
VL - 29
SP - 358
EP - 365
JO - Neurocritical care
JF - Neurocritical care
IS - 3
ER -