TY - JOUR
T1 - Cerebral atrophy measurements using jacobian integration
T2 - Comparison with the boundary shift integral
AU - Boyes, Richard G.
AU - Rueckert, Daniel
AU - Aljabar, Paul
AU - Whitwell, Jennifer
AU - Schott, Jonathan M.
AU - Hill, Derek L.G.
AU - Fox, Nicholas C.
N1 - Funding Information:
This work was supported by the Medical Research Council (UK), the Alzheimers Society (UK) and the Engineering and Physical Sciences Research Council (EPSRC) (UK), including grant GR/S08916/01. The authors gratefully acknowledge David McManus who performed the scan acquisition in this study, and Valerie Anderson and Jo Barnes for their helpful comments.
PY - 2006
Y1 - 2006
N2 - We compared two methods of measuring cerebral atrophy in a cohort of 38 clinically probable Alzheimer's disease (AD) subjects and 22 agematched normal controls, using metrics of zero atrophy, consistency, scaled atrophy and AD/control group separation. The two methods compared were the boundary shift integral (BSI) and a technique based on the integration of Jacobian determinants from non-rigid registration. For each subject, we used two volumetric magnetic resonance (MR) scans at baseline and a third obtained 1 year later. The case of zero atrophy was established by registering the sameday baseline scan pair, which should approximate zero change. Consistency was established by registering the 1-year follow-up scan to each of the baseline scans, giving two measurements of atrophy that should be very similar, while scaled atrophy was established by reducing one of the same-day scans by a fixed amount, and rigidly registering this to the other same-day scan. Group separation was ascertained by calculating atrophy rates over the two 1-year measures for the control and AD subjects. The results showed the Jacobian integration technique was significantly more accurate in calculating scaled atrophy (P < 0.001) and was able to distinguish between control and AD subjects more clearly (P < 0.01).
AB - We compared two methods of measuring cerebral atrophy in a cohort of 38 clinically probable Alzheimer's disease (AD) subjects and 22 agematched normal controls, using metrics of zero atrophy, consistency, scaled atrophy and AD/control group separation. The two methods compared were the boundary shift integral (BSI) and a technique based on the integration of Jacobian determinants from non-rigid registration. For each subject, we used two volumetric magnetic resonance (MR) scans at baseline and a third obtained 1 year later. The case of zero atrophy was established by registering the sameday baseline scan pair, which should approximate zero change. Consistency was established by registering the 1-year follow-up scan to each of the baseline scans, giving two measurements of atrophy that should be very similar, while scaled atrophy was established by reducing one of the same-day scans by a fixed amount, and rigidly registering this to the other same-day scan. Group separation was ascertained by calculating atrophy rates over the two 1-year measures for the control and AD subjects. The results showed the Jacobian integration technique was significantly more accurate in calculating scaled atrophy (P < 0.001) and was able to distinguish between control and AD subjects more clearly (P < 0.01).
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U2 - 10.1016/j.neuroimage.2006.02.052
DO - 10.1016/j.neuroimage.2006.02.052
M3 - Article
C2 - 16675272
AN - SCOPUS:33748649688
SN - 1053-8119
VL - 32
SP - 159
EP - 169
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -