Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy

F. Earnest IV; P. J. Kelly; B. W. Scheithauer; B. A. Kall; T. L. Cascino; R. L. Ehman; G. S. Forbes; P. L. Axley

doi:10.1148/radiology.166.3.2829270

Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy

F. Earnest IV, P. J. Kelly, B. W. Scheithauer, B. A. Kall, T. L. Cascino, R. L. Ehman, G. S. Forbes, P. L. Axley

Radiology

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Abstract

Gadolinium-labeled diethylenetriaminepentaacetic acid was used as a contrast agent for stereotactic magnetic resonance (MR) imaging in six selected patients with brain tumors who underwent stereotactic biopsy. Regions of contrast enhancement demonstrated by computed tomography (CT) and MR imaging in four of the six patients correlated with areas of malignant neovascularity and endothelial proliferation within solid tumor. Radiation necrosis produced contrast enhancement indistinguishable from that recurrent neoplasm. Isolated tumor cells within intact white matter were identified in biopsy specimens obtained outside of regions that were depicted as abnormal by contrast material-enhanced CT, as well as by precontrast and postcontrast T1- and T2-weighted MR images.

Original language	English (US)
Pages (from-to)	823-827
Number of pages	5
Journal	Radiology
Volume	166
Issue number	3
DOIs	https://doi.org/10.1148/radiology.166.3.2829270
State	Published - Jan 1 1988

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.166.3.2829270

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title = "Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy",

abstract = "Gadolinium-labeled diethylenetriaminepentaacetic acid was used as a contrast agent for stereotactic magnetic resonance (MR) imaging in six selected patients with brain tumors who underwent stereotactic biopsy. Regions of contrast enhancement demonstrated by computed tomography (CT) and MR imaging in four of the six patients correlated with areas of malignant neovascularity and endothelial proliferation within solid tumor. Radiation necrosis produced contrast enhancement indistinguishable from that recurrent neoplasm. Isolated tumor cells within intact white matter were identified in biopsy specimens obtained outside of regions that were depicted as abnormal by contrast material-enhanced CT, as well as by precontrast and postcontrast T1- and T2-weighted MR images.",

author = "{Earnest IV}, F. and Kelly, {P. J.} and Scheithauer, {B. W.} and Kall, {B. A.} and Cascino, {T. L.} and Ehman, {R. L.} and Forbes, {G. S.} and Axley, {P. L.}",

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T2 - Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy

AU - Earnest IV, F.

AU - Kelly, P. J.

AU - Scheithauer, B. W.

AU - Kall, B. A.

AU - Cascino, T. L.

AU - Ehman, R. L.

AU - Forbes, G. S.

AU - Axley, P. L.

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AB - Gadolinium-labeled diethylenetriaminepentaacetic acid was used as a contrast agent for stereotactic magnetic resonance (MR) imaging in six selected patients with brain tumors who underwent stereotactic biopsy. Regions of contrast enhancement demonstrated by computed tomography (CT) and MR imaging in four of the six patients correlated with areas of malignant neovascularity and endothelial proliferation within solid tumor. Radiation necrosis produced contrast enhancement indistinguishable from that recurrent neoplasm. Isolated tumor cells within intact white matter were identified in biopsy specimens obtained outside of regions that were depicted as abnormal by contrast material-enhanced CT, as well as by precontrast and postcontrast T1- and T2-weighted MR images.

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Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy

Abstract

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