Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy

F. Earnest IV, P. J. Kelly, B. W. Scheithauer, B. A. Kall, T. L. Cascino, R. L. Ehman, G. S. Forbes, P. L. Axley

Research output: Contribution to journalArticle

280 Scopus citations

Abstract

Gadolinium-labeled diethylenetriaminepentaacetic acid was used as a contrast agent for stereotactic magnetic resonance (MR) imaging in six selected patients with brain tumors who underwent stereotactic biopsy. Regions of contrast enhancement demonstrated by computed tomography (CT) and MR imaging in four of the six patients correlated with areas of malignant neovascularity and endothelial proliferation within solid tumor. Radiation necrosis produced contrast enhancement indistinguishable from that recurrent neoplasm. Isolated tumor cells within intact white matter were identified in biopsy specimens obtained outside of regions that were depicted as abnormal by contrast material-enhanced CT, as well as by precontrast and postcontrast T1- and T2-weighted MR images.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalRadiology
Volume166
Issue number3
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Earnest IV, F., Kelly, P. J., Scheithauer, B. W., Kall, B. A., Cascino, T. L., Ehman, R. L., Forbes, G. S., & Axley, P. L. (1988). Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy. Radiology, 166(3), 823-827. https://doi.org/10.1148/radiology.166.3.2829270