Abstract
Objective: To describe imaging findings as well as postmortem brain and cardiac pathology in a patient with fulminant idiopathic hypereosinophilic syndrome Design: Case report. Setting: University hospital. Patient: A 48-year-old right-handed man with hypere- osinophilia, rapidly progressive encephalopathy, and focal neurological deficits who died 22 days after presentation. Main Outcome Measures: Physical examination, ra- diologic, and neuropathologic examination results. Results: Imaging of the brain revealed bihemispheric is- chemic changes in and beyond the watershed distributions. Pathology review demonstrated mural cardiac thrombus that likely caused cardioembolism as well as diffuse microangiopathy despite resolution of the hy- pereosinophilia. Conclusions: Timely recognition of idiopathic hypere- osinophilic syndrome may enable aggressive treatment prior to widespread cardioembolism and degranulation that result in devastating cerebrovascular complications.
Original language | English (US) |
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Pages (from-to) | 528-531 |
Number of pages | 4 |
Journal | Archives of neurology |
Volume | 66 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2009 |
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology