Cerebral amyloid angiopathy: CT and MR imaging findings

Christine P. Chao, Amy L. Kotsenas, Daniel F. Broderick

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Cerebral amyloid angiopathy (CAA) is an important but underrecognized cause of cerebrovascular disorders that predominantly affect elderly patients. CAA results from deposition of β-amyloid protein in cortical, subcortical, and leptomeningeal vessels. This deposition is responsible for the wide spectrum of clinical symptoms and neuroimaging findings. Many cases of CAA are asymptomatic. However, when cases are symptomatic, patients can present with transient neurologic events, progressive cognitive decline, or potentially devastating intracranial hemorrhage. Computed tomography is the imaging study of choice for evaluation of suspected acute cortical hemorrhage, which may be accompanied by subarachnoid, subdural, or intraventricular hemorrhage. Magnetic resonance imaging is best suited for identification of small or chronic cortical hemorrhages and ischemic sequelae of this disease, exclusion of other causes of acute cortical-subcortical hemorrhage, and assessment of disease progression. Accurate recognition of imaging findings is important in guiding clinical decision making in patients with CAA.

Original languageEnglish (US)
Pages (from-to)1517-1531
Number of pages15
JournalRadiographics
Volume26
Issue number5
DOIs
StatePublished - 2006

Fingerprint

Cerebral Amyloid Angiopathy
Hemorrhage
Amyloidogenic Proteins
Cerebrovascular Disorders
Intracranial Hemorrhages
Neuroimaging
Nervous System
Disease Progression
Tomography
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Chao, C. P., Kotsenas, A. L., & Broderick, D. F. (2006). Cerebral amyloid angiopathy: CT and MR imaging findings. Radiographics, 26(5), 1517-1531. https://doi.org/10.1148/rg.265055090

Cerebral amyloid angiopathy : CT and MR imaging findings. / Chao, Christine P.; Kotsenas, Amy L.; Broderick, Daniel F.

In: Radiographics, Vol. 26, No. 5, 2006, p. 1517-1531.

Research output: Contribution to journalArticle

Chao, CP, Kotsenas, AL & Broderick, DF 2006, 'Cerebral amyloid angiopathy: CT and MR imaging findings', Radiographics, vol. 26, no. 5, pp. 1517-1531. https://doi.org/10.1148/rg.265055090
Chao, Christine P. ; Kotsenas, Amy L. ; Broderick, Daniel F. / Cerebral amyloid angiopathy : CT and MR imaging findings. In: Radiographics. 2006 ; Vol. 26, No. 5. pp. 1517-1531.
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