Cerebellar volume loss in radiologically isolated syndrome

Ilena C. George; Mohamed Mounir El Mendili; Matilde Inglese; Christina J. Azevedo; Orhun Kantarci; Christine Lebrun; Aksel Siva; Darin T. Okuda; Daniel Pelletier

doi:10.1177/1352458519887346

Cerebellar volume loss in radiologically isolated syndrome

Ilena C. George, Mohamed Mounir El Mendili, Matilde Inglese, Christina J. Azevedo, Orhun Kantarci, Christine Lebrun, Aksel Siva, Darin T. Okuda, Daniel Pelletier

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.

Original language	English (US)
Pages (from-to)	130-133
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	27
Issue number	1
DOIs	https://doi.org/10.1177/1352458519887346
State	Published - Jan 2021

Keywords

Radiologically isolated syndrome
brainstem
cerebellar atrophy
cerebellum
multiple sclerosis
white matter lesions

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1177/1352458519887346

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title = "Cerebellar volume loss in radiologically isolated syndrome",

abstract = "Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.",

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T1 - Cerebellar volume loss in radiologically isolated syndrome

AU - George, Ilena C.

AU - El Mendili, Mohamed Mounir

AU - Inglese, Matilde

AU - Azevedo, Christina J.

AU - Kantarci, Orhun

AU - Lebrun, Christine

AU - Siva, Aksel

AU - Okuda, Darin T.

AU - Pelletier, Daniel

N1 - Publisher Copyright: © The Author(s), 2019.

PY - 2021/1

Y1 - 2021/1

N2 - Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.

AB - Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.

KW - Radiologically isolated syndrome

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KW - cerebellar atrophy

KW - cerebellum

KW - multiple sclerosis

KW - white matter lesions

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Cerebellar volume loss in radiologically isolated syndrome

Abstract

Keywords

ASJC Scopus subject areas

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