Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma

Yi Zhou, Marc K. Rosenblum, Ahmet Dogan, Achim A. Jungbluth, April Chiu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL. EBV-encoded RNAs were detected in the DLBCL, suggesting that EBV played a pivotal role in the pathogenesis of high-grade histologic progression of AITL. The patient survived less than 9 months after his initial diagnosis of AITL. We believe that this case expands the spectrum of extranodal manifestation of EBV-positive B cell lymphoma associated with AITL and illustrates the importance of recognition of this association when encountering unusual central nervous system lesions in patients with known AITL.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalJournal of Hematopathology
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2015

Keywords

  • Angioimmunoblastic T cell lymphoma
  • Central nervous system
  • Diffuse large B cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

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