Abstract
Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL. EBV-encoded RNAs were detected in the DLBCL, suggesting that EBV played a pivotal role in the pathogenesis of high-grade histologic progression of AITL. The patient survived less than 9 months after his initial diagnosis of AITL. We believe that this case expands the spectrum of extranodal manifestation of EBV-positive B cell lymphoma associated with AITL and illustrates the importance of recognition of this association when encountering unusual central nervous system lesions in patients with known AITL.
Original language | English (US) |
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Pages (from-to) | 235-241 |
Number of pages | 7 |
Journal | Journal of Hematopathology |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2015 |
Keywords
- Angioimmunoblastic T cell lymphoma
- Central nervous system
- Diffuse large B cell lymphoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Hematology