Abstract
The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal function of the centrosome and on its orderly duplication, once and only once, in each cell cycle. Malignant tumor cells show characteristic defects in cell and tissue architecture and in chromosome number that can be attributed to inappropriate centrosome behavior during tumor progression. In this review, we will summarize recent observations linking centrosome defects to disruption of normal cell and tissue organization and to chromosomal instability found in malignant tumors. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 451-460 |
| Number of pages | 10 |
| Journal | Biology of the Cell |
| Volume | 91 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1999 |
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Keywords
- Aneuploidy
- Boveri
- Cell polarity
- Centrioles
- Chromosomal instability
- Malignant cells
ASJC Scopus subject areas
- Cell Biology
Cite this
Centrosomes and cancer. / Salisbury, Jeffrey L; Whitehead, Clark M.; Lingle, Wilma L.; Barrett, Susan L.
In: Biology of the Cell, Vol. 91, No. 6, 1999, p. 451-460.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Centrosomes and cancer
AU - Salisbury, Jeffrey L
AU - Whitehead, Clark M.
AU - Lingle, Wilma L.
AU - Barrett, Susan L.
PY - 1999
Y1 - 1999
N2 - The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal function of the centrosome and on its orderly duplication, once and only once, in each cell cycle. Malignant tumor cells show characteristic defects in cell and tissue architecture and in chromosome number that can be attributed to inappropriate centrosome behavior during tumor progression. In this review, we will summarize recent observations linking centrosome defects to disruption of normal cell and tissue organization and to chromosomal instability found in malignant tumors. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
AB - The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal function of the centrosome and on its orderly duplication, once and only once, in each cell cycle. Malignant tumor cells show characteristic defects in cell and tissue architecture and in chromosome number that can be attributed to inappropriate centrosome behavior during tumor progression. In this review, we will summarize recent observations linking centrosome defects to disruption of normal cell and tissue organization and to chromosomal instability found in malignant tumors. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
KW - Aneuploidy
KW - Boveri
KW - Cell polarity
KW - Centrioles
KW - Chromosomal instability
KW - Malignant cells
UR - http://www.scopus.com/inward/record.url?scp=0033304092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033304092&partnerID=8YFLogxK
U2 - 10.1016/S0248-4900(99)80086-0
DO - 10.1016/S0248-4900(99)80086-0
M3 - Article
C2 - 10519005
AN - SCOPUS:0033304092
VL - 91
SP - 451
EP - 460
JO - Biology of the Cell
JF - Biology of the Cell
SN - 0248-4900
IS - 6
ER -