Centrosomes and cancer

Jeffrey L. Salisbury; Clark M. Whitehead; Wilma L. Lingle; Susan L. Barrett

doi:10.1016/S0248-4900(99)80086-0

Centrosomes and cancer

Jeffrey L. Salisbury, Clark M. Whitehead, Wilma L. Lingle, Susan L. Barrett

Research output: Contribution to journal › Review article

102 Scopus citations

Abstract

The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal function of the centrosome and on its orderly duplication, once and only once, in each cell cycle. Malignant tumor cells show characteristic defects in cell and tissue architecture and in chromosome number that can be attributed to inappropriate centrosome behavior during tumor progression. In this review, we will summarize recent observations linking centrosome defects to disruption of normal cell and tissue organization and to chromosomal instability found in malignant tumors. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

Original language	English (US)
Pages (from-to)	451-460
Number of pages	10
Journal	Biology of the Cell
Volume	91
Issue number	6
DOIs	https://doi.org/10.1016/S0248-4900(99)80086-0
State	Published - Jan 1 1999

Keywords

Aneuploidy
Boveri
Cell polarity
Centrioles
Chromosomal instability
Malignant cells

ASJC Scopus subject areas

Cell Biology

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10.1016/S0248-4900(99)80086-0

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Salisbury, J. L., Whitehead, C. M., Lingle, W. L., & Barrett, S. L. (1999). Centrosomes and cancer. Biology of the Cell, 91(6), 451-460. https://doi.org/10.1016/S0248-4900(99)80086-0

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