Centrosome dynamics as a source of chromosomal instability

Hyun Ja Nam, Ryan M. Naylor, Jan M. van Deursen

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Accurate segregation of duplicated chromosomes between two daughter cells depends on bipolar spindle formation, a metaphase state in which sister kinetochores are attached to microtubules emanating from opposite spindle poles. To ensure bi-orientation, cells possess surveillance systems that safeguard against microtubule-kinetochore attachment defects, including the spindle assembly checkpoint and the error correction machinery. However, recent developments have identified centrosome dynamics - that is, centrosome disjunction and poleward movement of duplicated centrosomes - as a central target for deregulation of bi-orientation in cancer cells. In this review, we discuss novel insights into the mechanisms that underlie centrosome dynamics and discuss how these mechanisms are perturbed in cancer cells to drive chromosome mis-segregation and advance neoplastic transformation.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalTrends in Cell Biology
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Cancer
  • Centrosome disjunction
  • Centrosome dynamics
  • Centrosome movement
  • Chromosomal instability

ASJC Scopus subject areas

  • Cell Biology

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