Abstract
Background Deep brain stimulation (DBS) of the centromedian-parafascicular (CM-Pf) thalamic nuclei has been considered an option for treating Tourette syndrome. Using a large animal DBS model, this study was designed to explore the network effects of CM-Pf DBS. Methods The combination of DBS and functional magnetic resonance imaging is a powerful means of tracing brain circuitry and testing the modulatory effects of electrical stimulation on a neuronal network in vivo. With a within-subjects design, we tested the proportional effects of CM and Pf DBS by manipulating current spread and varying stimulation contacts in healthy pigs (n = 5). Results Our results suggests that CM-Pf DBS has an inhibitory modulating effect in areas that have been suggested as contributing to impaired sensory-motor and emotional processing. The results also help to define the differential neural circuitry effects of the CM and Pf with evidence of prominent sensorimotor/associative effects for CM DBS and prominent limbic/associative effects for Pf DBS. Conclusions Our results support the notion that stimulation of deep brain structures, such as the CM-Pf, modulates multiple networks with cortical effects. The networks affected by CM-Pf stimulation in this study reinforce the conceptualization of Tourette syndrome as a condition with psychiatric and motor symptoms and of CM-Pf DBS as a potentially effective tool for treating both types of symptoms.
Original language | English (US) |
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Pages (from-to) | 917-926 |
Number of pages | 10 |
Journal | Biological psychiatry |
Volume | 74 |
Issue number | 12 |
DOIs | |
State | Published - Dec 15 2013 |
Keywords
- Centromedian
- Tourette syndrome
- deep brain stimulation (DBS)
- functional magnetic resonance imaging (fMRI)
- neural circuitry
- parafascicular
- swine model
ASJC Scopus subject areas
- Biological Psychiatry