Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals

Joo Pyung Kim, Hoon Ki Min, Emily J. Knight, Penelope S. Duffy, Osama A. Abulseoud, Michael P. Marsh, Katherine Kelsey, Charles D. Blaha, Kevin E. Bennet, Mark A Frye, Kendall H Lee

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background Deep brain stimulation (DBS) of the centromedian-parafascicular (CM-Pf) thalamic nuclei has been considered an option for treating Tourette syndrome. Using a large animal DBS model, this study was designed to explore the network effects of CM-Pf DBS. Methods The combination of DBS and functional magnetic resonance imaging is a powerful means of tracing brain circuitry and testing the modulatory effects of electrical stimulation on a neuronal network in vivo. With a within-subjects design, we tested the proportional effects of CM and Pf DBS by manipulating current spread and varying stimulation contacts in healthy pigs (n = 5). Results Our results suggests that CM-Pf DBS has an inhibitory modulating effect in areas that have been suggested as contributing to impaired sensory-motor and emotional processing. The results also help to define the differential neural circuitry effects of the CM and Pf with evidence of prominent sensorimotor/associative effects for CM DBS and prominent limbic/associative effects for Pf DBS. Conclusions Our results support the notion that stimulation of deep brain structures, such as the CM-Pf, modulates multiple networks with cortical effects. The networks affected by CM-Pf stimulation in this study reinforce the conceptualization of Tourette syndrome as a condition with psychiatric and motor symptoms and of CM-Pf DBS as a potentially effective tool for treating both types of symptoms.

Original languageEnglish (US)
Pages (from-to)917-926
Number of pages10
JournalBiological Psychiatry
Volume74
Issue number12
DOIs
StatePublished - Dec 15 2013

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Deep Brain Stimulation
Intralaminar Thalamic Nuclei
Tourette Syndrome
Inhibition (Psychology)
Electric Stimulation
Psychiatry
Swine
Magnetic Resonance Imaging

Keywords

  • Centromedian
  • deep brain stimulation (DBS)
  • functional magnetic resonance imaging (fMRI)
  • neural circuitry
  • parafascicular
  • swine model
  • Tourette syndrome

ASJC Scopus subject areas

  • Biological Psychiatry
  • Medicine(all)

Cite this

Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals. / Kim, Joo Pyung; Min, Hoon Ki; Knight, Emily J.; Duffy, Penelope S.; Abulseoud, Osama A.; Marsh, Michael P.; Kelsey, Katherine; Blaha, Charles D.; Bennet, Kevin E.; Frye, Mark A; Lee, Kendall H.

In: Biological Psychiatry, Vol. 74, No. 12, 15.12.2013, p. 917-926.

Research output: Contribution to journalArticle

Kim, Joo Pyung ; Min, Hoon Ki ; Knight, Emily J. ; Duffy, Penelope S. ; Abulseoud, Osama A. ; Marsh, Michael P. ; Kelsey, Katherine ; Blaha, Charles D. ; Bennet, Kevin E. ; Frye, Mark A ; Lee, Kendall H. / Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals. In: Biological Psychiatry. 2013 ; Vol. 74, No. 12. pp. 917-926.
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