TY - JOUR
T1 - Centrin, centrosomes, and mitotic spindle poles
AU - Satisbury, Jeffrey L.
PY - 1995
Y1 - 1995
N2 - Centrin is a ubiquitous protein component of centrosomes and mitotic spindle poles. cDNA clones encoding centrin have been identified from vertebrate sources, and their sequences demonstrate that centrin is a highly conserved member of the EF-hand superfamily of calcium-binding proteins. Analysis of yeast and Chlamydomonas centrin mutants and experimentalstudies suggest that centrin has an essential role in the duplication of the centrosomes during the cell cycle, and in microtubule severing.
AB - Centrin is a ubiquitous protein component of centrosomes and mitotic spindle poles. cDNA clones encoding centrin have been identified from vertebrate sources, and their sequences demonstrate that centrin is a highly conserved member of the EF-hand superfamily of calcium-binding proteins. Analysis of yeast and Chlamydomonas centrin mutants and experimentalstudies suggest that centrin has an essential role in the duplication of the centrosomes during the cell cycle, and in microtubule severing.
KW - SPB-spindle pole body
UR - http://www.scopus.com/inward/record.url?scp=0028928790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028928790&partnerID=8YFLogxK
U2 - 10.1016/0955-0674(95)80043-3
DO - 10.1016/0955-0674(95)80043-3
M3 - Article
C2 - 7755988
AN - SCOPUS:0028928790
SN - 0955-0674
VL - 7
SP - 39
EP - 45
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -