Centrin, centrosomes, and mitotic spindle poles

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307 Scopus citations


Centrin is a ubiquitous protein component of centrosomes and mitotic spindle poles. cDNA clones encoding centrin have been identified from vertebrate sources, and their sequences demonstrate that centrin is a highly conserved member of the EF-hand superfamily of calcium-binding proteins. Analysis of yeast and Chlamydomonas centrin mutants and experimentalstudies suggest that centrin has an essential role in the duplication of the centrosomes during the cell cycle, and in microtubule severing.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - 1995


  • SPB-spindle pole body

ASJC Scopus subject areas

  • Cell Biology


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