Centrin, centrosomes, and mitotic spindle poles

Research output: Contribution to journalArticle

303 Scopus citations

Abstract

Centrin is a ubiquitous protein component of centrosomes and mitotic spindle poles. cDNA clones encoding centrin have been identified from vertebrate sources, and their sequences demonstrate that centrin is a highly conserved member of the EF-hand superfamily of calcium-binding proteins. Analysis of yeast and Chlamydomonas centrin mutants and experimentalstudies suggest that centrin has an essential role in the duplication of the centrosomes during the cell cycle, and in microtubule severing.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume7
Issue number1
DOIs
StatePublished - 1995

Keywords

  • SPB-spindle pole body

ASJC Scopus subject areas

  • Cell Biology

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