PURPOSE: To report central serous chorioretinopathy associated with excessive use of compounds with sympathomimetic activity. DESIGN: Observational case series. METHODS: Four patients presented with clinical and fluorescein angiographic evidence of central serous chorioretinopathy. All patients expressed a concomitant psychogenic stress and high-dose ingestion of pseudoephedrine, oxymetazoline, or 3,4-methylenedioxymethamphetamine, all of which possess sympathomimetic properties. RESULTS: In all cases, resolution of central serous chorioretinopathy coincided with cessation of the medication. CONCLUSIONS: Patients afflicted with central serous chorioretinopathy should be notified about its possible association with sympathomimetic medications.
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