Central neurocytomas

Steven E. Schild, Bernd W. Scheithauer, Michael Haddock, David Schiff, Peter C. Burger, William W. Wong, Mark K. Lyons

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

BACKGROUND. This analysis was performecd to examine the outcome of patients with histologically confirmed central neurocytomas. METHODS. Thirty- two patients with histologically confirmed central neurocytomas were evaluated retrospectively. Patients were treated with various combinations of surgery, chemotherapy, and radiotherapy (RT). Follow-up ranged from 2.3 to 15.3 years (median, 4.7 years). RESULTS. The overall 5-year survival and local control rates were 81% and 79% respectively. No patient developed metastases. The 5-year local control rate was 70% for patients undergoing subtotal resection (STR) and 100% for those undergoing gross total resection (GTR) (P = 0.08). The 5-year survival rate was 77% for patients undergoing STR and 90% for those undergoing GTR (P = 0.44). The effect of RT was evaluated for patients undergoing STR. The 5-year local control rate was 100% for patients who received RT after STR compared with 50% for those who did not (P = 0.02). The 5-year survial rate was 88% for patients who received RT after STR compared with 71% for those who did not (P = 0.3). Three patients received salvage RT for local progression after resection. All were alive and free of disease 1 to 6 years after RT. CONCLUSIONS. GTR results in a very high likelihood of local control and servival. Postoperative RT appears to improve local control rates significantly for patients who have undergone STR. The overall prognosis of patients with central neurocytomas is quite favorable, with an actuarial 5-year survival rate of 81%.

Original languageEnglish (US)
Pages (from-to)790-795
Number of pages6
JournalCancer
Volume79
Issue number4
DOIs
StatePublished - Feb 15 1997

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Keywords

  • central neurocytoma
  • chemotherapy
  • radiation therapy
  • surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Schild, S. E., Scheithauer, B. W., Haddock, M., Schiff, D., Burger, P. C., Wong, W. W., & Lyons, M. K. (1997). Central neurocytomas. Cancer, 79(4), 790-795. https://doi.org/10.1002/(SICI)1097-0142(19970215)79:4<790::AID-CNCR16>3.0.CO;2-V