Central neurocytoma: Clinical characteristics, patterns of care, and survival

Sunil W. Dutta, Tasneem A. Kaleem, Donald A. Muller, Jennifer Peterson, Anna C. Harrell, Alfredo Quinones-Hinojosa, Daniel Trifiletti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To investigate clinical characteristics and patterns of care among patients with central neurocytomas in a large cohort of patients. Methods: The National Cancer Database (NCDB) was queried to identify patients with biopsy confirmed neurocytoma from 2004 to 2015. Patterns of care were described and univariable and multivariable models were performed to investigate the impact of prognostic factors on overall survival. Results: Among 223,404 patients with brain tumors in the NCDB, 868 patients were diagnosed with biopsy-proven neurocytoma and analyzed (0.4% or approximately 75 patients annually). Median age at diagnosis was 31 years and median tumor size was 4–5 cm. Diagnosis was similar between male (49.5%) and female (50.5%). Regarding location, 622 (72%) tumors were intraventricular, 168 (19%) were extra-ventricular, and 78 (9%) overlapping or unspecified. Five-year overall survival among all patients was 89%. On multivariable analysis tumor location, extent of resection, and use of radiation, were not predictive for improved survival (each p > 0.05); however, patient age (p < 0.001), WHO grade (p < 0.001), and medical comorbidity scores (p = 0.002) were independently associated with overall survival. Conclusion: Patients with central neurocytoma often present as young adults with sizable tumor burden and are well managed with surgery alone. Considering their favorable survival, efforts to improve tumor control should be carefully weighed against the long-term risks associated with adjuvant therapy like radiation.

Original languageEnglish (US)
JournalJournal of Clinical Neuroscience
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Neurocytoma
Survival
Neoplasms
Databases
Biopsy
Tumor Burden
Brain Neoplasms
Comorbidity
Young Adult
Patient Care
Radiotherapy
Radiation

Keywords

  • Database
  • NCDB
  • Neurocytoma
  • Outcomes
  • Radiation
  • Resection

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Central neurocytoma : Clinical characteristics, patterns of care, and survival. / Dutta, Sunil W.; Kaleem, Tasneem A.; Muller, Donald A.; Peterson, Jennifer; Harrell, Anna C.; Quinones-Hinojosa, Alfredo; Trifiletti, Daniel.

In: Journal of Clinical Neuroscience, 01.01.2018.

Research output: Contribution to journalArticle

Dutta, Sunil W. ; Kaleem, Tasneem A. ; Muller, Donald A. ; Peterson, Jennifer ; Harrell, Anna C. ; Quinones-Hinojosa, Alfredo ; Trifiletti, Daniel. / Central neurocytoma : Clinical characteristics, patterns of care, and survival. In: Journal of Clinical Neuroscience. 2018.
@article{f1060dcb4df948c29271ba6e849cb514,
title = "Central neurocytoma: Clinical characteristics, patterns of care, and survival",
abstract = "Purpose: To investigate clinical characteristics and patterns of care among patients with central neurocytomas in a large cohort of patients. Methods: The National Cancer Database (NCDB) was queried to identify patients with biopsy confirmed neurocytoma from 2004 to 2015. Patterns of care were described and univariable and multivariable models were performed to investigate the impact of prognostic factors on overall survival. Results: Among 223,404 patients with brain tumors in the NCDB, 868 patients were diagnosed with biopsy-proven neurocytoma and analyzed (0.4{\%} or approximately 75 patients annually). Median age at diagnosis was 31 years and median tumor size was 4–5 cm. Diagnosis was similar between male (49.5{\%}) and female (50.5{\%}). Regarding location, 622 (72{\%}) tumors were intraventricular, 168 (19{\%}) were extra-ventricular, and 78 (9{\%}) overlapping or unspecified. Five-year overall survival among all patients was 89{\%}. On multivariable analysis tumor location, extent of resection, and use of radiation, were not predictive for improved survival (each p > 0.05); however, patient age (p < 0.001), WHO grade (p < 0.001), and medical comorbidity scores (p = 0.002) were independently associated with overall survival. Conclusion: Patients with central neurocytoma often present as young adults with sizable tumor burden and are well managed with surgery alone. Considering their favorable survival, efforts to improve tumor control should be carefully weighed against the long-term risks associated with adjuvant therapy like radiation.",
keywords = "Database, NCDB, Neurocytoma, Outcomes, Radiation, Resection",
author = "Dutta, {Sunil W.} and Kaleem, {Tasneem A.} and Muller, {Donald A.} and Jennifer Peterson and Harrell, {Anna C.} and Alfredo Quinones-Hinojosa and Daniel Trifiletti",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jocn.2018.04.015",
language = "English (US)",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Central neurocytoma

T2 - Clinical characteristics, patterns of care, and survival

AU - Dutta, Sunil W.

AU - Kaleem, Tasneem A.

AU - Muller, Donald A.

AU - Peterson, Jennifer

AU - Harrell, Anna C.

AU - Quinones-Hinojosa, Alfredo

AU - Trifiletti, Daniel

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To investigate clinical characteristics and patterns of care among patients with central neurocytomas in a large cohort of patients. Methods: The National Cancer Database (NCDB) was queried to identify patients with biopsy confirmed neurocytoma from 2004 to 2015. Patterns of care were described and univariable and multivariable models were performed to investigate the impact of prognostic factors on overall survival. Results: Among 223,404 patients with brain tumors in the NCDB, 868 patients were diagnosed with biopsy-proven neurocytoma and analyzed (0.4% or approximately 75 patients annually). Median age at diagnosis was 31 years and median tumor size was 4–5 cm. Diagnosis was similar between male (49.5%) and female (50.5%). Regarding location, 622 (72%) tumors were intraventricular, 168 (19%) were extra-ventricular, and 78 (9%) overlapping or unspecified. Five-year overall survival among all patients was 89%. On multivariable analysis tumor location, extent of resection, and use of radiation, were not predictive for improved survival (each p > 0.05); however, patient age (p < 0.001), WHO grade (p < 0.001), and medical comorbidity scores (p = 0.002) were independently associated with overall survival. Conclusion: Patients with central neurocytoma often present as young adults with sizable tumor burden and are well managed with surgery alone. Considering their favorable survival, efforts to improve tumor control should be carefully weighed against the long-term risks associated with adjuvant therapy like radiation.

AB - Purpose: To investigate clinical characteristics and patterns of care among patients with central neurocytomas in a large cohort of patients. Methods: The National Cancer Database (NCDB) was queried to identify patients with biopsy confirmed neurocytoma from 2004 to 2015. Patterns of care were described and univariable and multivariable models were performed to investigate the impact of prognostic factors on overall survival. Results: Among 223,404 patients with brain tumors in the NCDB, 868 patients were diagnosed with biopsy-proven neurocytoma and analyzed (0.4% or approximately 75 patients annually). Median age at diagnosis was 31 years and median tumor size was 4–5 cm. Diagnosis was similar between male (49.5%) and female (50.5%). Regarding location, 622 (72%) tumors were intraventricular, 168 (19%) were extra-ventricular, and 78 (9%) overlapping or unspecified. Five-year overall survival among all patients was 89%. On multivariable analysis tumor location, extent of resection, and use of radiation, were not predictive for improved survival (each p > 0.05); however, patient age (p < 0.001), WHO grade (p < 0.001), and medical comorbidity scores (p = 0.002) were independently associated with overall survival. Conclusion: Patients with central neurocytoma often present as young adults with sizable tumor burden and are well managed with surgery alone. Considering their favorable survival, efforts to improve tumor control should be carefully weighed against the long-term risks associated with adjuvant therapy like radiation.

KW - Database

KW - NCDB

KW - Neurocytoma

KW - Outcomes

KW - Radiation

KW - Resection

UR - http://www.scopus.com/inward/record.url?scp=85045839097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045839097&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2018.04.015

DO - 10.1016/j.jocn.2018.04.015

M3 - Article

C2 - 29685410

AN - SCOPUS:85045839097

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

ER -