Central nervous system involvement by mantle cell lymphoma

Nicole McLaughlin; Yucai Wang; Thomas Witzig; Jose Villasboas; Thomas Habermann; David Inwards; Nora Bennani; Gita Thanarajasingam; Grzegorz Nowakowski; Luis Porrata; Carrie Thompson; Ivana Micallef; Patrick Johnston; Stephen Ansell; Jonas Paludo

doi:10.1080/10428194.2022.2148211

Central nervous system involvement by mantle cell lymphoma

Nicole McLaughlin, Yucai Wang, Thomas Witzig, Jose Villasboas, Thomas Habermann, David Inwards, Nora Bennani, Gita Thanarajasingam, Grzegorz Nowakowski, Luis Porrata, Carrie Thompson, Ivana Micallef, Patrick Johnston, Stephen Ansell, Jonas Paludo

Hematology

Research output: Contribution to journal › Article › peer-review

Abstract

Involvement of the central nervous system (CNS) is a rare complication of mantle cell lymphoma (MCL) with limited treatment options. We report the outcomes of 36 patients with CNS involvement compared to 72 matched control MCL patients without CNS involvement. Four patients (11%) with CNS MCL were diagnosed with CNS involvement at time of MCL diagnosis. Median OS from MCL diagnosis was 50.3 months (95% CI: 22.8–79.6) for the CNS MCL group compared to 97.1 months (95% CI: 82.8–NR; p= <0.001) for the control group. Median OS from CNS involvement was 4.7 months (95% CI: 2.3–6.7). CNS involvement by MCL has dismal outcomes as evident by a short median OS and PFS after CNS involvement. Advanced stage, blastoid variant, elevated LDH, and elevated Ki67 at MCL diagnosis were features more commonly seen in the CNS MCL cohort.

Original language	English (US)
Pages (from-to)	371-377
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	64
Issue number	2
DOIs	https://doi.org/10.1080/10428194.2022.2148211
State	Published - 2023

Keywords

BTK inhibitors
Non-Hodgkin lymphoma
brain
treatment

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1080/10428194.2022.2148211

Cite this

@article{b67e9675243345728250dea510980c99,

title = "Central nervous system involvement by mantle cell lymphoma",

abstract = "Involvement of the central nervous system (CNS) is a rare complication of mantle cell lymphoma (MCL) with limited treatment options. We report the outcomes of 36 patients with CNS involvement compared to 72 matched control MCL patients without CNS involvement. Four patients (11%) with CNS MCL were diagnosed with CNS involvement at time of MCL diagnosis. Median OS from MCL diagnosis was 50.3 months (95% CI: 22.8–79.6) for the CNS MCL group compared to 97.1 months (95% CI: 82.8–NR; p= <0.001) for the control group. Median OS from CNS involvement was 4.7 months (95% CI: 2.3–6.7). CNS involvement by MCL has dismal outcomes as evident by a short median OS and PFS after CNS involvement. Advanced stage, blastoid variant, elevated LDH, and elevated Ki67 at MCL diagnosis were features more commonly seen in the CNS MCL cohort.",

keywords = "BTK inhibitors, Non-Hodgkin lymphoma, brain, treatment",

author = "Nicole McLaughlin and Yucai Wang and Thomas Witzig and Jose Villasboas and Thomas Habermann and David Inwards and Nora Bennani and Gita Thanarajasingam and Grzegorz Nowakowski and Luis Porrata and Carrie Thompson and Ivana Micallef and Patrick Johnston and Stephen Ansell and Jonas Paludo",

note = "Publisher Copyright: {\textcopyright} 2022 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2023",

doi = "10.1080/10428194.2022.2148211",

language = "English (US)",

volume = "64",

pages = "371--377",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Informa Healthcare",

number = "2",

}

TY - JOUR

T1 - Central nervous system involvement by mantle cell lymphoma

AU - McLaughlin, Nicole

AU - Wang, Yucai

AU - Witzig, Thomas

AU - Villasboas, Jose

AU - Habermann, Thomas

AU - Inwards, David

AU - Bennani, Nora

AU - Thanarajasingam, Gita

AU - Nowakowski, Grzegorz

AU - Porrata, Luis

AU - Thompson, Carrie

AU - Micallef, Ivana

AU - Johnston, Patrick

AU - Ansell, Stephen

AU - Paludo, Jonas

PY - 2023

Y1 - 2023

N2 - Involvement of the central nervous system (CNS) is a rare complication of mantle cell lymphoma (MCL) with limited treatment options. We report the outcomes of 36 patients with CNS involvement compared to 72 matched control MCL patients without CNS involvement. Four patients (11%) with CNS MCL were diagnosed with CNS involvement at time of MCL diagnosis. Median OS from MCL diagnosis was 50.3 months (95% CI: 22.8–79.6) for the CNS MCL group compared to 97.1 months (95% CI: 82.8–NR; p= <0.001) for the control group. Median OS from CNS involvement was 4.7 months (95% CI: 2.3–6.7). CNS involvement by MCL has dismal outcomes as evident by a short median OS and PFS after CNS involvement. Advanced stage, blastoid variant, elevated LDH, and elevated Ki67 at MCL diagnosis were features more commonly seen in the CNS MCL cohort.

AB - Involvement of the central nervous system (CNS) is a rare complication of mantle cell lymphoma (MCL) with limited treatment options. We report the outcomes of 36 patients with CNS involvement compared to 72 matched control MCL patients without CNS involvement. Four patients (11%) with CNS MCL were diagnosed with CNS involvement at time of MCL diagnosis. Median OS from MCL diagnosis was 50.3 months (95% CI: 22.8–79.6) for the CNS MCL group compared to 97.1 months (95% CI: 82.8–NR; p= <0.001) for the control group. Median OS from CNS involvement was 4.7 months (95% CI: 2.3–6.7). CNS involvement by MCL has dismal outcomes as evident by a short median OS and PFS after CNS involvement. Advanced stage, blastoid variant, elevated LDH, and elevated Ki67 at MCL diagnosis were features more commonly seen in the CNS MCL cohort.

KW - BTK inhibitors

KW - Non-Hodgkin lymphoma

KW - brain

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=85142380736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85142380736&partnerID=8YFLogxK

U2 - 10.1080/10428194.2022.2148211

DO - 10.1080/10428194.2022.2148211

M3 - Article

C2 - 36416595

AN - SCOPUS:85142380736

SN - 1042-8194

VL - 64

SP - 371

EP - 377

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 2

ER -

Central nervous system involvement by mantle cell lymphoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this