Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. SchmittJohn Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

The cellular state of “senescence” has proven difficult to define, presenting an obstacle for progress in the field. This perspective provides a consensus on the cellular and molecular features of senescence from 26 field leaders.

Original languageEnglish (US)
Pages (from-to)813-827
Number of pages15
JournalCell
Volume179
Issue number4
DOIs
StatePublished - Oct 31 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A. B., Narita, M., Niedernhofer, L., Passos, J. F., Robbins, P. D., ... Demaria, M. (2019). Cellular Senescence: Defining a Path Forward. Cell, 179(4), 813-827. https://doi.org/10.1016/j.cell.2019.10.005