Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Yi Zhu, Jacqueline L. Armstrong, Tamara Tchkonia, James L. Kirkland

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations

Abstract

Possible mechanisms in cellular senescence and the senescence-Associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered. RECENT FINDINGS: A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging. SUMMARY: Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalCurrent opinion in clinical nutrition and metabolic care
Volume17
Issue number4
DOIs
StatePublished - Jul 2014

Keywords

  • Inflammation
  • Senescence
  • Senescence-Associated secretory phenotype

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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