Cellular Senescence and the Immune System in Cancer

Luis I. Prieto, Darren J Baker

Research output: Contribution to journalReview article

Abstract

In response to a variety of cancer-inducing stresses, cells may engage a stable cell cycle arrest mechanism, termed cellular senescence, to suppress the proliferation of preneoplastic cells. Despite this cell intrinsic tumor suppression, senescent cells have also been implicated as active contributors to tumorigenesis by extrinsically promoting many hallmarks of cancer, including evasion of the immune system. Here, we discuss these dual, and seemingly contradictory, roles of senescence during tumorigenesis. Furthermore, we highlight findings of how senescent cells can influence the immune system and discuss the possibility that immune cells themselves may be acquiring senescence-associated alterations. Lastly, we discuss how senescent cell avoidance or clearance may impact pathology.

Original languageEnglish (US)
Pages (from-to)505-512
Number of pages8
JournalGerontology
Volume65
Issue number5
DOIs
StatePublished - Jan 1 2019

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Cell Aging
Immune System
Neoplasms
Carcinogenesis
Cell Cycle Checkpoints
Cell Proliferation
Pathology

Keywords

  • Cellular senescence
  • Immunosenescence
  • Senolytics
  • Tumorigenesis

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Cellular Senescence and the Immune System in Cancer. / Prieto, Luis I.; Baker, Darren J.

In: Gerontology, Vol. 65, No. 5, 01.01.2019, p. 505-512.

Research output: Contribution to journalReview article

Prieto, Luis I. ; Baker, Darren J. / Cellular Senescence and the Immune System in Cancer. In: Gerontology. 2019 ; Vol. 65, No. 5. pp. 505-512.
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