Abstract
Senescence is a multi-functional cell fate, characterized by an irreversible cell-cycle arrest and a pro-inflammatory phenotype, commonly known as the senescence-associated secretory phenotype (SASP). Emerging evidence indicates that accumulation of senescent cells in multiple tissues drives tissue dysfunction and several age-related conditions. This has spurred the academic community and industry to identify new therapeutic interventions targeting this process. Mitochondrial dysfunction is an often-unappreciated hallmark of cellular senescence which plays important roles not only in the senescence growth arrest but also in the development of the SASP and resistance to cell-death. Here, we review the evidence that supports a role for mitochondria in the development of senescence and describe the underlying mechanisms. Finally, we propose that a detailed road map of mitochondrial biology in senescence will be crucial to guide the future development of senotherapies.
Original language | English (US) |
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Pages (from-to) | 1186-1202 |
Number of pages | 17 |
Journal | FEBS Journal |
Volume | 290 |
Issue number | 5 |
DOIs | |
State | Published - Mar 2023 |
Keywords
- SASP
- ageing
- mitochondria
- senescence
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Cell Biology