Cellular senescence: A new player in kidney injury

Yongxin Li, Lilach O. Lerman

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Kidney diseases secondary to several pathogeneses affect millions of people worldwide and have become increasingly recognized as a global public health problem. Recent evidence suggests that cellular senescence plays an important role in the pathogenesis of different forms of renal damage, including acute and chronic kidney disease, and renal transplantation. Renal senescence involves cell cycle arrest and affects several cellular pathways, manifesting in downregulation of klotho, elevated expression of cyclin-dependent kinase inhibitors, cellular telomere shortening, and oxidative stress. Furthermore, senescent cells might induce kidney injury by paracrine release of inflammatory factors. Yet, cellular senescence may be renoprotective during development and in some models of renal diseases, reflecting the yin/yang duality of cellular senescence. This review provides an overview of the role of this emerging player in renal injury, with emphasis on new findings of cellular senescence.

Original languageEnglish (US)
Pages (from-to)1069-1075
Number of pages7
JournalHypertension
DOIs
StateAccepted/In press - 2020

Keywords

  • acute kidney injury
  • aging
  • kidney
  • public health
  • renal insufficiency, chronic

ASJC Scopus subject areas

  • Internal Medicine

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