@inproceedings{220712449a8143b9bbcabbd1efac12b7,
title = "Cellular response of ovarian carcinoma cells to antibody-photosensitizer-mediated injury",
abstract = "An anti-ovarian carcinoma antibody OC125 was conjugated to a derivative of the photosensitizer (PS) chlorin e6 via polyglutamic acid. Target cells from a human ovarian cancer cell line were treated with this conjugate and laser irradiation at 656 nm (absorption maximum of PS) and fixed 24 h later for electron microscopy. Electron micrographs showed a high degree of vacoulization, generalized cell necrosis, and extrusion of organelles. No specific damage to the plasma membrane was noted. Untreated control cells, or cells treated with conjugate or light alone exhibited no injury. These data suggest that even though the antibody recognizes a cell surface antigen, the conjugate is internalized under the conditions of the experiment.",
author = "T. Hasan and Sherwood, {M. E.} and T. Anderson and M. Bamberg and Flotte, {T. J.} and Zurawski, {V. R.}",
year = "1990",
doi = "10.1117/12.17657",
language = "English (US)",
isbn = "0819402443",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "Publ by Int Soc for Optical Engineering",
pages = "136--152",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",
note = "Proceedings of Photodynamic Therapy: Mechanisms II ; Conference date: 16-01-1990 Through 17-01-1990",
}