Cellular models for tau filament assembly

Li Wen Ko, Michael Deture, Naruhiko Sahara, Rifki Chihab, Shu Hui Yen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Filamentous inclusions made of phosphorylated tau constitute a neuropathologic hallmark of Alzheimer's disease and related disorders. Because abnormal accumulation of tau correlates with the decline in cognitive function, it is conceivable that effective intervention at the early stage of tau filament assembly could impede the progression of these neurodegnerative diseases. Cellular models recapitulating the tau aberration are useful for screening and identifying compounds that are capable of interfering with tau aggregation in a cost-effective manner. To develop such cell culture models, we have established from human neuroglioma [H4] and neuronal [BE(2)-M17D] cells conditional transfectants whose transgenic expression of wild-type or mutant tau via inducible expression mechanisms leads to tau aggregation and filament assembly.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalJournal of Molecular Neuroscience
Volume19
Issue number3
StatePublished - Dec 2002

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Cognition
Disease Progression
Alzheimer Disease
Agglomeration
Cell Culture Techniques
Costs and Cost Analysis
Aberrations
Cell culture
Screening
Costs

Keywords

  • Alzheimer's disease
  • Conditional transfectants
  • FTDP-17
  • Tau filaments

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry
  • Genetics

Cite this

Ko, L. W., Deture, M., Sahara, N., Chihab, R., & Yen, S. H. (2002). Cellular models for tau filament assembly. Journal of Molecular Neuroscience, 19(3), 311-316.

Cellular models for tau filament assembly. / Ko, Li Wen; Deture, Michael; Sahara, Naruhiko; Chihab, Rifki; Yen, Shu Hui.

In: Journal of Molecular Neuroscience, Vol. 19, No. 3, 12.2002, p. 311-316.

Research output: Contribution to journalArticle

Ko, LW, Deture, M, Sahara, N, Chihab, R & Yen, SH 2002, 'Cellular models for tau filament assembly', Journal of Molecular Neuroscience, vol. 19, no. 3, pp. 311-316.
Ko LW, Deture M, Sahara N, Chihab R, Yen SH. Cellular models for tau filament assembly. Journal of Molecular Neuroscience. 2002 Dec;19(3):311-316.
Ko, Li Wen ; Deture, Michael ; Sahara, Naruhiko ; Chihab, Rifki ; Yen, Shu Hui. / Cellular models for tau filament assembly. In: Journal of Molecular Neuroscience. 2002 ; Vol. 19, No. 3. pp. 311-316.
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