Cellular Immunity: A Role for Cytokines

DeLisa Fairweather, M. Afanasyeva, N. R. Rose

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The heart is a remarkably durable and efficient pump that provides all cells of the body with nutrients and removes waste products. Myocarditis is a process characterized by an inflammatory infiltrate of the myocardium with necrosis and/or degeneration of adjacent myocytes not typical of the ischemic damage associated with coronary artery disease. Autoimmune heart disease following viral infection involves the production of key cytokines by immune cells such as macrophages and natural killer cells. Finally, if environmental or genetic factors allow overproduction of proinflammatory cytokines, then progression to chronic autoimmune myocarditis may follow. Importantly, myocarditis often precedes the development of dilated cardiomyopathy, which can lead to heart failure and the need for cardiac transplantation.

Original languageEnglish (US)
Title of host publicationHandbook of Systemic Autoimmune Diseases
PublisherElsevier Ltd
Pages1-29
Number of pages29
Volume14
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameHandbook of Systemic Autoimmune Diseases
Volume14
ISSN (Print)1571-5078

Keywords

  • Autoimmunity
  • Inflammation
  • Myocarditis
  • Myocytes
  • Natural killer

ASJC Scopus subject areas

  • Immunology and Allergy
  • Endocrinology, Diabetes and Metabolism

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  • Cite this

    Fairweather, D., Afanasyeva, M., & Rose, N. R. (2017). Cellular Immunity: A Role for Cytokines. In Handbook of Systemic Autoimmune Diseases (Vol. 14, pp. 1-29). (Handbook of Systemic Autoimmune Diseases; Vol. 14). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-803997-7.00001-6