Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow

Soo Young Yoon, Ayalew Tefferi, Chin Yang Li

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

We performed an immunohistochemical study on 5 normal marrow samples and 3 fibrotic marrow samples to investigate the cellular distribution of various isoforms of platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and their corresponding receptors. Immature hematopoietic precursors strongly expressed PDGF-B, all the TGF-β isoforms, PDGFRβ, TGFβRI and II, and FGFR1, 3, and 4. Megakaryocytes stained primarily for PDGF-B, TGF-β2-3 and PDGFRβ. Histiocytes displayed intense TGF-β1, bFGF, and FGFR2 expression. Fibroblasts and endothelial cells carried receptors for all the aforementioned cytokines. The last 2 cell types also expressed the ligand cytokines to varied degrees.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalActa Haematologica
Volume104
Issue number4
DOIs
StatePublished - Dec 1 2000

Keywords

  • Basic fibroblast growth factor
  • Bone marrow
  • Cytokine
  • Immunohistochemistry
  • Isotype
  • Myelofibrosis
  • Platelet-derived growth factor
  • Receptors
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Hematology

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