Cellular automaton model for simulating tissue-specific intestinal electrophysiological activity

Jerry Gao, Peng Du, Greg O'Grady, Rosalind Archer, Simon J. Gibbons, Gianrico Farrugia, Leo K. Cheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Depletion of interstitial cell of Cajal (ICC) networks is known to occur in various gastrointestinal (GI) motility disorders. Although techniques for quantifying the structure of ICC networks are available, the ICC network structure-function relationships are yet to be well elucidated. Existing methods of relating ICC structure to function are computationally expensive, and it is difficult to up-scale them to larger multiscale simulations. A new cellular automaton model for simulating tissue-specific slow wave propagation was developed, and in preliminary studies the automaton model was applied on jejunal ICC network structures from wild-type and 5-HT2B receptor knockout (ICC depleted) mice. Two metrics were also developed to quantify the simulated propagation patterns: 1) ICC and 2) non-ICC activation lag metrics. These metrics measured the average delay in time taken for the slow wave to propagate across the ICC and non-ICC domain throughout the entire network compared to the theoretical fastest propagation, respectively. Slow wave propagation was successfully simulated across the ICC networks with greatly reduced computational time compared to previous methods, and the propagation pattern metrics quantitatively revealed an impaired propagation during ICC depletion. In conclusion, the developed slow wave propagation model and propagation pattern metrics offer a computationally efficient framework for relating ICC structure to function. These tools can now be further applied to define ICC structure-function relationships across various spatial and temporal scales.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages5537-5540
Number of pages4
DOIs
StatePublished - 2013
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: Jul 3 2013Jul 7 2013

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period7/3/137/7/13

Fingerprint

Interstitial Cells of Cajal
Cellular automata
Tissue
Wave propagation
Chemical activation
Cells
Receptor, Serotonin, 5-HT2B
Gastrointestinal Motility

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Gao, J., Du, P., O'Grady, G., Archer, R., Gibbons, S. J., Farrugia, G., & Cheng, L. K. (2013). Cellular automaton model for simulating tissue-specific intestinal electrophysiological activity. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 5537-5540). [6610804] https://doi.org/10.1109/EMBC.2013.6610804

Cellular automaton model for simulating tissue-specific intestinal electrophysiological activity. / Gao, Jerry; Du, Peng; O'Grady, Greg; Archer, Rosalind; Gibbons, Simon J.; Farrugia, Gianrico; Cheng, Leo K.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. p. 5537-5540 6610804.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gao, J, Du, P, O'Grady, G, Archer, R, Gibbons, SJ, Farrugia, G & Cheng, LK 2013, Cellular automaton model for simulating tissue-specific intestinal electrophysiological activity. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6610804, pp. 5537-5540, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 7/3/13. https://doi.org/10.1109/EMBC.2013.6610804
Gao J, Du P, O'Grady G, Archer R, Gibbons SJ, Farrugia G et al. Cellular automaton model for simulating tissue-specific intestinal electrophysiological activity. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. p. 5537-5540. 6610804 https://doi.org/10.1109/EMBC.2013.6610804
Gao, Jerry ; Du, Peng ; O'Grady, Greg ; Archer, Rosalind ; Gibbons, Simon J. ; Farrugia, Gianrico ; Cheng, Leo K. / Cellular automaton model for simulating tissue-specific intestinal electrophysiological activity. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. pp. 5537-5540
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